Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor.
CD68 and Sema4D protein expression was significantly associated with histological differentiation, TNM stage, and lymph node metastasis (<i>P</i> < 0.05), and their expression levels were positively correlated with one another (<i>r</i> = 0.467, <i>P</i> < 0.01).
However, little is known regarding the functional relationship between Sema4D and VEGF-C/VEGF-D and in the mediation of lymphangiogenesis and lymph node metastasis and clinical outcome.
The overexpression of Sema4D and of its receptor, plexinB1, was found to be significantly correlated with clinical factors, such as lymph node metastasis, distant metastasis, and poor prognosis in patients with PDAC.