DisGeNET - a database of gene-disease associations

SEMA4D, semaphorin 4D, 10507

N. diseases: 109; N. variants: 9

Disease: Carcinoma, Ovarian Epithelial ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

Biomarker

disease

BEFREE

Here, we try to further understand the mechanism by which SEMA4D promotes angiogenesis in ovarian cancer.

29308068

2018

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

AlteredExpression

disease

BEFREE

Regulation of semaphorin 4D expression and cell proliferation of ovarian cancer by ERalpha and ERbeta.

28225892

2017

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

Biomarker

disease

BEFREE

MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D.

26718213

2016

CUI:	C4721610
Disease:	Carcinoma, Ovarian Epithelial

Carcinoma, Ovarian Epithelial

0.040

Biomarker

disease

BEFREE

Thus SEMA4D and its role in macrophage polarization in EOC warrants further study.

24289594

2013