|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
This study clarifies how DNAM-1 modifies the bidirectional crosstalk of NK cells with CD155<sup>+</sup> DC, which can be exploited to suppress CNS autoimmunity and strengthen tumor surveillance.
|
30808363 |
2019 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, our study reveals that a VAV1-based, synergistic cross-talk exists between the TCR and CD226 during both physiological and pathological T cell responses and provides a rational basis for targeting CD226 for the management of autoimmune diseases.
|
29991650 |
2018 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders.
|
29338153 |
2017 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
These novel findings confirmed that CD226 played a pivotal role in mediating autoimmune diseases such as EAE.
|
26942885 |
2016 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases.
|
26634488 |
2015 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis provided evidence that CD226 Gly307Ser (rs763361) is significantly associated with the risk of multiple autoimmune diseases.
|
23073294 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Taken together, our results establish an important role for CD226 in differentially regulating the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance, suggesting that the CD226/CD155 interaction could potentially be targeted in therapeutic approaches to human autoimmune diseases.
|
23980210 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc).
|
22531499 |
2012 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population.
|
22512842 |
2012 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity.
|
21162102 |
2011 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Our results demonstrate that the IL2/IL21 region, C8orf13-BLK, and CD226 influence RA in Colombians, and RA shares some of the pathogenic mechanisms associated with other autoimmune diseases.
|
21765104 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many autoimmune disorders.
|
21521299 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases.
|
20887380 |
2011 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
However, shared autoimmunity with CD226 has not been evaluated in non-European populations.
|
20338887 |
2010 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
LHGDN |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |