|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
In general, results from the current study indicate that CD226 and HLA-G, but not CD58 genetic polymorphisms are associated with increased risk of MS in Isfahan population similar to European populations.
|
30128676 |
2018 |
|
Multiple Sclerosis
|
0.180 |
AlteredExpression
|
disease |
BEFREE |
Mimicking the phenotype of human CD226 genetic risk variant carriers, regulatory T cells derived from Cd226-deficient mice showed similarly reduced inhibitory activity, eventually resulting in an exacerbated disease course of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis.
|
26359290 |
2015 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
|
22190364 |
2011 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805).
|
20952449 |
2011 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds ratio (OR)=1.13, 95% confidence interval (CI)=1.05-1.23); rs3184504 in SH2B3 (P=0.00001, OR=1.19, 95% CI=1.10-1.27) and rs763361 in CD226 (P=0.00007, OR=1.16, 95%CI=1.08-1.25).
|
20508602 |
2010 |
|
Multiple Sclerosis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.
|
19536154 |
2009 |
|
Multiple Sclerosis
|
0.180 |
Biomarker
|
disease |
LHGDN |
The expanding genetic overlap between multiple sclerosis and type I diabetes.
|
18987646 |
2009 |