|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Chronic mild stress impairs latent inhibition and induces region-specific neural activation in CHL1-deficient mice, a mouse model of schizophrenia.
|
28647594 |
2017 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
One of the genes associated with schizophrenia is the Close Homolog of L1 (CHL1); CHL1-deficient mice are considered a model of schizophrenia-like deficits, including sensorimotor gating, interval timing and spatial memory impairments.
|
28583411 |
2017 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the associations of single nucleotides polymorphisms (SNPs) of the CHL1 gene locus, including rs2055314 (C/T), rs2272522 (C/T) and rs331894 (A/G), with schizophrenia in the Qatari population.
|
23857787 |
2013 |
|
Schizophrenia
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The most notable genome-wide transcriptome difference between LCLs displaying high versus low paroxetine sensitivities was a 6.3-fold lower (p = 0.0000256) basal expression of CHL1, a gene coding for a neuronal cell adhesion protein implicated in correct thalamocortical circuitry, schizophrenia and autism.
|
21332311 |
2011 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our results confirm the positive association between CHL1 gene and schizophrenia and indicate that CHL1 may be involved in the etiology of schizophrenia.
|
15653271 |
2005 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
CTD_human |
Our results confirm the positive association between CHL1 gene and schizophrenia and indicate that CHL1 may be involved in the etiology of schizophrenia.
|
15653271 |
2005 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
An association between this CHL1 gene polymorphism and schizophrenia supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia.
|
11986985 |
2002 |
|
Schizophrenia
|
0.360 |
Biomarker
|
disease |
CTD_human |
An association between this CHL1 gene polymorphism and schizophrenia supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia.
|
11986985 |
2002 |
|
Schizophrenia
|
0.360 |
GeneticVariation
|
disease |
LHGDN |
An association between this CHL1 gene polymorphism and schizophrenia supports the notion that cell adhesion molecules are involved in the etiology of schizophrenia.
|
11986985 |
2002 |
|
Intellectual Disability
|
0.320 |
Biomarker
|
group |
BEFREE |
However, the description of both deletions and duplications of chromosome 3p26.3 in nonsyndromic intellectual disability suggests that CHL1 is a dosage-sensitive gene with an important role for normal cognitive development.
|
23436495 |
2013 |
|
Intellectual Disability
|
0.320 |
Biomarker
|
group |
CTD_human |
This suggests that the CALL gene at 3p26.3 is a prime candidate for an autosomal form of mental retardation.
|
12812975 |
2003 |
|
Intellectual Disability
|
0.320 |
GeneticVariation
|
group |
BEFREE |
This suggests that the CALL gene at 3p26.3 is a prime candidate for an autosomal form of mental retardation.
|
12812975 |
2003 |
|
Colorectal Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Specifically; CHL1, 4 anti-inflammatory genes (i.e., NELL1, GDF1, ARHGEF4, and ITGA4), and 7 miRNAs (of which miR-9-3p and miR-124-3p have been implicated in CRC) were hypermethylated in DNA samples from AA patients with CRC.
|
27111221 |
2016 |
|
Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Fetal Alcohol Syndrome
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion.
|
21367865 |
2011 |
|
Fetal Alcohol Spectrum Disorders
|
0.300 |
Biomarker
|
group |
PSYGENET |
Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion.
|
21367865 |
2011 |
|
Profound Mental Retardation
|
0.300 |
Biomarker
|
disease |
CTD_human |
CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior.
|
12812975 |
2003 |
|
Mental Retardation, Psychosocial
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior.
|
12812975 |
2003 |
|
Mental deficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior.
|
12812975 |
2003 |
|
Adolescent idiopathic scoliosis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Adolescent idiopathic scoliosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study.
|
24512353 |
2014 |
|
Hair Color
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
|
30531825 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Polysomnography
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
23251661 |
2012 |
|
Alanine aminotransferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
|
23251661 |
2012 |