CYGB, cytoglobin, 114757

N. diseases: 88; N. variants: 6
Disease: Renal fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.220 Biomarker disease BEFREE Several antioxidant and renoprotective agents, including cysteamine bitartrate, epoxyeicosatrienoic acids (EETs), and cytoglobin (Cygb) have demonstrated ameliorative effects on renal fibrosis in preclinical or clinical studies. 29503620 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.220 AlteredExpression disease BEFREE In vitro studies revealed that overexpression of cytoglobin suppressed phosphorylation of Smad2, ERK, and p38 induced by TGF-β and expression of NF-kB, α-SMA, and TGF-β RI.LDP prevented renal fibrosis and protected glomerular mesangial cells by upregulation of cytoglobin and suppression of multiple pathways involving TGF-β/SMADS, MAPK, NF-kB signaling. 28099346 2017
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.220 Therapeutic disease RGD To clarify the role of Cygb in kidney fibrosis, we employed the remnant kidney model in rats. 20719976 2010