Anti-CIRP Ab or CIRP-derived small peptide may have effective therapeutic potentials in sepsis, acute lung injury, and organ ischemia/reperfusion injuries.
Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner.
Conversely, the CIRP<sup>-/-</sup> mice showed significant inhibition in the frequencies and numbers of ICAM-1<sup>+</sup> neutrophils in the lungs compared to wild-type (WT) mice in sepsis.
To test this hypothesis, we studied the lungs of wild-type (WT) and CIRP knockout (KO) mice at 20 h after induction of sepsis by cecal ligation and puncture (CLP).