ADORA2B, adenosine A2b receptor, 136

N. diseases: 66; N. variants: 2
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease BEFREE Deficiency of methylthioadenosine phosphorylase (MTAP) supports melanoma development and progression through accumulation of its substrate 5'-methylthioadenosine (MTA), which leads amongst others to a constitutive inhibition of protein arginine methyltransferases (PRMTs) and activation of the transcription factor AP-1 via the receptor ADORA2B. 27479139 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE The metabolite 5'-methylthioadenosine signals through the adenosine receptor A2B in melanoma. 25087184 2014