|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
The RV function of coupled with the pulmonary circulation (tricuspid annular plane systolic excursion [TAPSE]/pulmonary arterial systolic pressure [PASP]) has been shown to divide HF patients into distinct prognostic strata, but less is known about which factors influence this prognostic marker, and whether those factors can be modified.
|
30472282 |
2019 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
The RV function of coupled with the pulmonary circulation (tricuspid annular plane systolic excursion [TAPSE]/pulmonary arterial systolic pressure [PASP]) has been shown to divide HF patients into distinct prognostic strata, but less is known about which factors influence this prognostic marker, and whether those factors can be modified.
|
30472282 |
2019 |
|
Cerebrovascular accident
|
0.020 |
Biomarker
|
group |
BEFREE |
The cause of operative mortality in the no-CPB era was perioperative stroke in 4 patients and acute myocardial infarction in 1 patient.
|
30954589 |
2019 |
|
Dissection of proximal aorta
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
According to univariate analysis, age, irritability, alcohol use, extracorporeal circulation duration (cardiopulmonary bypass, CPB time), antegrade selective cerebral perfusion (ASCP) time, lowest partial pressure of oxygen (lowest PO2), mechanical ventilation time, blood loss, low PO₂ and oxygenation index, hemoglobin (Hb), Intensive Care Unit (ICU) stay, and dihydroxyphenylalanine (DEX) were associated with higher odds of POD among type A aortic dissection patients.
|
31102507 |
2019 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes.
|
29759300 |
2018 |
|
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although the PASP was slightly higher in patients with HF-PH with right ventricular dysfunction, pulmonary vascular remodeling was not more severe.
|
29246894 |
2018 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although the PASP was slightly higher in patients with HF-PH with right ventricular dysfunction, pulmonary vascular remodeling was not more severe.
|
29246894 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry of tissue microarray from 90 PDAC patients demonstrated that CPB1 was downregulated 7.07-fold (P<.0001, n=81) in tumor comparing with the peritumor tissue.
|
29631213 |
2018 |
|
Diabetes Mellitus
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The post-CPB protein levels of the inducible COX-2 were significantly increased compared with pre-CPB values in both the ND and DM groups (P < 0.05), whereas, this increase was higher in DM than that of ND (P < 0.05).
|
28985857 |
2017 |
|
Cerebrovascular accident
|
0.020 |
Biomarker
|
group |
BEFREE |
Multiple logistic regression showed that stroke (OR=7.846, 95% CI: 2.737-22.489, p<0.001), emergency (OR=2.198, 95% CI: 1.019-4.740, p=0.045), CPB time (OR=1.009, 95% CI: 1.004-1.014, p<0.001), CABG (OR=2.613, 95% CI: 1.066-6.405, p=0.036) and packed red blood cells (OR=1.113, 95% CI: 1.038-1.193, p=0.003) were independent predictors of adverse outcome, and acute type A aortic dissection (OR=2.635, 95% CI: 1.535-4.524, p<0.001), preoperative neurological deficits (OR=5.326, 95% CI: 1.529-18.548, p=0.009), CPB time (OR=1.004, 95% CI: 1.000-1.007, p=0.026) and cerebral low-flow time (OR=1.034, 95% CI: 1.003-1.066, p=0.033) were associated with TND.
|
27637729 |
2017 |
|
Dissection of proximal aorta
|
0.020 |
Biomarker
|
disease |
BEFREE |
Multiple logistic regression showed that stroke (OR=7.846, 95% CI: 2.737-22.489, p<0.001), emergency (OR=2.198, 95% CI: 1.019-4.740, p=0.045), CPB time (OR=1.009, 95% CI: 1.004-1.014, p<0.001), CABG (OR=2.613, 95% CI: 1.066-6.405, p=0.036) and packed red blood cells (OR=1.113, 95% CI: 1.038-1.193, p=0.003) were independent predictors of adverse outcome, and acute type A aortic dissection (OR=2.635, 95% CI: 1.535-4.524, p<0.001), preoperative neurological deficits (OR=5.326, 95% CI: 1.529-18.548, p=0.009), CPB time (OR=1.004, 95% CI: 1.000-1.007, p=0.026) and cerebral low-flow time (OR=1.034, 95% CI: 1.003-1.066, p=0.033) were associated with TND.
|
27637729 |
2017 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased levels of carboxypeptidase B1 (CPB1), PDZ and LIM domain protein 2 (PDLIM2), and ring finger protein 25 (RNF25) were associated specifically with lymph node positive grade 1 tumors, whereas stathmin 1 (STMN1) and thymosin beta 10 (TMSB10) associated with aggressive tumor phenotype also in high grade tumors at both protein and transcript level.
|
25903579 |
2015 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that carboxypeptidase B (CPB) protects against joint erosion in rheumatoid arthritis by inactivating complement component C5a.
|
24449579 |
2014 |
|
Degenerative polyarthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, we used enzyme-linked immunosorbent assay, flow cytometry, and hemolytic assays to assess the effect of CPB on formation of membrane attack complex (MAC)-a complement effector critical to OA pathogenesis.
|
24449579 |
2014 |
|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Additionally, expression of both CPB and C5a in synovial fluid was higher in patients with RA than in those with osteoarthritis.
|
21804193 |
2011 |
|
Degenerative polyarthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Additionally, expression of both CPB and C5a in synovial fluid was higher in patients with RA than in those with osteoarthritis.
|
21804193 |
2011 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
MPV/PC ratio for reoperation for early vein-graft occlusion; MPV and ejection fraction for low cardiac output syndrome; hyperlipidemia, chronic renal failure history and MPV/PC ratio for sepsis; male gender, CRF history and CPB time for atrial fibrillation; age, congestive heart failure history, myocardial infarction history and CPB time for the early mortality were found to be independent predictors.
|
31515731 |
2019 |
|
Blood Coagulation Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the subgroup of patients with long CPB-times (> 115 min.; n = 55) known to exhibit an increased risk for diffuse coagulopathy ROTEM®-guided treatment resulted in a significantly lower 24-h drainage loss (ROTEM®: 1538.2 ± 806.4 ml vs. control: 2056.8 ± 974.5 ml; p = 0.032) and reduced 5-year mortality (ROTEM®: 0% vs. control: 15%; p = 0.03).
|
31694568 |
2019 |
|
Congenital Heart Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
Demographic and neurodevelopmental outcomes were tabulated to enable blinded statistical analysis comparing outcomes between N-CPB and H-CPB surgery for congenital heart defects.
|
31750278 |
2019 |
|
Ventricular Septal Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Although transthoracic device closure of VSD seems to be less traumatic and involves a quicker recovery, it also induces a systemic inflammatory response as measured by WBC count and PCT, CRP and IL-6 levels, and the altered trends in inflammatory markers were similar to those of conventional surgery under CPB.
|
30961628 |
2019 |
|
Leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results support CPB as a relevant antigen for canine leishmaniasis diagnosis in its different clinical presentations.
|
31434727 |
2019 |
|
Leishmaniasis, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our goal was to contribute to the diagnosis of canine cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) using the recombinant cysteine proteinase B (F-CPB) from <i>Leishmania braziliensis</i> and its N- and C-terminal domains (N-CPB and C-CPB) as antigens in an enzyme-linked immunosorbent assay (ELISA).
|
31434727 |
2019 |
|
Leishmaniasis, Visceral
|
0.010 |
Biomarker
|
disease |
BEFREE |
In sera from dogs diagnosed with VL from Northeast Argentina, we found Se of 93.3%, 73.3%, and 66.7% and Sp of 92.3%, 76.9%, and 88.5% for F-CPB and its N- and C-terminal domains, respectively.
|
31434727 |
2019 |