|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
During long-term carvedilol therapy, CHF patients with the Arg/Arg genotype of the ADRB1 gene were observed to have a more pronounced decrease in the functional class of heart failure, a significant increase in left ventricular ejection, and a decrease in left ventricular end-systolic and end-diastolic sizes as compared with patients with the Gly/Arg genotype.
|
21516734 |
2010 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
There were associations of the polymorphism of ADRB1 gene (the Gly39Arg polymorphic locus) with the development and severity of CHF and with the efficacy of therapy with beta-adrenoblocker carvedilol.
|
21516734 |
2010 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways.
|
15816327 |
2005 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
The control of cardiomyocyte apoptosis via the beta-adrenergic signaling pathways.
|
15816327 |
2005 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
|
14502278 |
2003 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
|
14502278 |
2003 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
|
12374873 |
2002 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
|
12374873 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats.
|
10673262 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
|
9260993 |
1997 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Long-term treatment with angiotensin I-converting enzyme inhibitors attenuates the loss of cardiac beta-adrenoceptor responses in rats with chronic heart failure.
|
7586371 |
1995 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Cardiac beta 1-adrenergic receptor density was decreased while its dissociation constant (Kd) was not altered in the viable tissue of the left ventricle of the CHF rat, which is consistent with beta-adrenergic receptor downregulation.
|
7586371 |
1995 |
|
Cardiomyopathy, Dilated
|
0.580 |
Biomarker
|
group |
CTD_human |
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
|
9554809 |
1998 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Protection against myocardial dysfunction induced by global ischemia-reperfusion by antisense-oligodeoxynucleotides directed at beta(1)-adrenoceptor mRNA.
|
10900253 |
2000 |
|
Cardiovascular Diseases
|
0.480 |
Biomarker
|
group |
CTD_human |
Assessment of systemic adverse reactions induced by ophthalmic beta-adrenergic receptor antagonists.
|
11436944 |
2001 |
|
Birth Weight
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
|
23202124 |
2013 |
|
Cardiomyopathy, Familial Idiopathic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
|
9554809 |
1998 |
|
Obesity
|
0.370 |
Biomarker
|
disease |
CTD_human |
We examined the association between Gly389Arg ADRB1 and obesity status in a large cohort of well-characterized individuals.
|
12032746 |
2002 |
|
Myocardial Ischemia
|
0.320 |
Biomarker
|
disease |
CTD_human |
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
|
9554809 |
1998 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
let-7e replacement yields potent anti-arrhythmic efficacy via targeting beta 1-adrenergic receptor in rat heart.
|
24758696 |
2014 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
let-7e replacement yields potent anti-arrhythmic efficacy via targeting beta 1-adrenergic receptor in rat heart.
|
24758696 |
2014 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
This study tested for an association between SLC18A2 and ADRB1 and treatment outcome in 873 major depressive disorder patients treated with the antidepressant citalopram in the Sequenced Treatment Alternatives to Relieve Depression study.
|
18797399 |
2008 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
This study tested for an association between SLC18A2 and ADRB1 and treatment outcome in 873 major depressive disorder patients treated with the antidepressant citalopram in the Sequenced Treatment Alternatives to Relieve Depression study.
|
18797399 |
2008 |
|
Hyperemia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genetic influences of beta-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients.
|
17345787 |
2006 |
|
Mood Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Further, several genome scans for mood disorders, both unipolar and bipolar, have indicated linkage to the chromosomal regions of 5q23-q33.3, 8p12-p11.2, 4p16, and 10q24-q26, the location of the adrenergic receptors alpha1B (ADRA1B), beta3 (ADRB3), alpha2C (ADRA2C), alpha2A (ADRA2A), and beta1 (ADRB1).
|
16526032 |
2006 |