Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
|
30820047 |
2019 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.
|
10643899 |
1999 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Alzheimer disease risk and genetic variation in ACE: a meta-analysis.
|
14872014 |
2004 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
|
17192785 |
2007 |
Alzheimer's Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease.
|
9916793 |
1999 |
Allanson Pantzar McLeod syndrome
|
0.760 |
Biomarker
|
disease |
CTD_human |
We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1.
|
16116425 |
2005 |
Allanson Pantzar McLeod syndrome
|
0.760 |
Biomarker
|
disease |
CTD_human |
Patient with RTD in Lisbon, Portugal, maintained by peritoneal dialysis since birth, was found to have a homozygous substitution of Arg for Glu at position 1069 in the C-terminal domain of ACE (Q1069R) resulting in absence of plasma ACE activity; both parents and a brother who are heterozygous carriers of this mutation had exactly half-normal plasma ACE activity compared to healthy individuals.
|
20454656 |
2010 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
CTD_human |
Influence of insertion/deletion polymorphism in the ACE-I gene on the progression of diabetic glomerulopathy in type 1 diabetic patients with microalbuminuria.
|
10857950 |
2000 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene.
|
7909524 |
1994 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
CTD_human |
Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats.
|
23733546 |
2013 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
CTD_human |
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.
|
10099885 |
1999 |
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
|
18586661 |
2008 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Long-term FAD286/spironolactone prevented CHF-related enhancement in LV ACE and reduction in LV ACE-2, but only FAD286 prevented the reduction in LV AT(2) receptors.
|
18586661 |
2008 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats.
|
27847271 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting enzyme in spontaneously hypertensive rats.
|
20237592 |
2010 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives.
|
15773232 |
2005 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
CTD_human |
The results indicate that deletion polymorphism in the ACE gene, particularly the homozygote DD, is a risk factor for progression to chronic renal failure in IgA nephropathy.
|
7593601 |
1995 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
CTD_human |
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.
|
10099885 |
1999 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE).
|
1328889 |
1992 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
CTD_human |
The ACE polymorphism may be an important genetic marker of MI risk and contribute to clustering of premature MI in families.
|
8131300 |
1993 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
|
15534175 |
2004 |
Left Ventricular Hypertrophy
|
0.600 |
Biomarker
|
disease |
CTD_human |
Systolic blood pressure, plasma renin activity, and cardiac angiotensin converting enzyme activity of L-NAME rats with left ventricular hypertrophy were significantly higher than those of the subgroup without.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8349331 |
1993 |
Lung diseases
|
0.560 |
Biomarker
|
group |
CTD_human |
Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.
|
18702808 |
2008 |
Albuminuria
|
0.510 |
Biomarker
|
phenotype |
CTD_human |
Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats.
|
23733546 |
2013 |
Diabetes Mellitus, Experimental
|
0.500 |
Biomarker
|
disease |
CTD_human |
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment.
|
22191573 |
2012 |