ACE, angiotensin I converting enzyme, 1636

N. diseases: 101; N. variants: 18
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.900 Biomarker disease GENOMICS_ENGLAND
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.760 Biomarker disease GENOMICS_ENGLAND
CUI: C2675470
Disease: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding)
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding) 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C2675470
Disease: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding)
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 3 (finding) 		0.500 Biomarker disease CTD_human
CUI: C0020649
Disease: Hypotension
Hypotension 		0.400 Therapeutic phenotype CTD_human Abnormal blood pressure recovery during ganglion blockade in diabetic rats. 3544871 1987
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker disease CTD_human In a study comparing patients after myocardial infarction with controls, we have explored a possible association between coronary heart disease and a variation found in the gene encoding angiotensin-converting enzyme (ACE). 1328889 1992
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker disease CTD_human The ACE polymorphism may be an important genetic marker of MI risk and contribute to clustering of premature MI in families. 8131300 1993
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.600 Biomarker disease CTD_human Systolic blood pressure, plasma renin activity, and cardiac angiotensin converting enzyme activity of L-NAME rats with left ventricular hypertrophy were significantly higher than those of the subgroup without.(ABSTRACT TRUNCATED AT 250 WORDS) 8349331 1993
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease CTD_human Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene. 7909524 1994
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.400 Biomarker disease CTD_human We have investigated the role of angiotensin-converting enzyme (ACE; EC 3.4.15.1) gene in 316 unrelated NIDDM individuals, 132 who had myocardial infarction or significant coronary stenoses and 184 with no history of coronary heart disease (CHD). 8170965 1994
CUI: C0017667
Disease: Nodular glomerulosclerosis
Nodular glomerulosclerosis 		0.320 Biomarker disease CTD_human Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene. 7909524 1994
CUI: C0038160
Disease: Staphylococcal Infections
Staphylococcal Infections 		0.300 Biomarker group CTD_human Activity of serum angiotensin converting enzyme in septic pigs treated with intrapulmonary corticosteroid. 8186310 1994
CUI: C1318973
Disease: Staphylococcus aureus infection
Staphylococcus aureus infection 		0.300 Biomarker disease CTD_human Activity of serum angiotensin converting enzyme in septic pigs treated with intrapulmonary corticosteroid. 8186310 1994
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.600 Biomarker disease CTD_human The results indicate that deletion polymorphism in the ACE gene, particularly the homozygote DD, is a risk factor for progression to chronic renal failure in IgA nephropathy. 7593601 1995
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.400 Biomarker disease CTD_human The results indicate that deletion polymorphism in the ACE gene, particularly the homozygote DD, is a risk factor for progression to chronic renal failure in IgA nephropathy. 7593601 1995
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.400 Biomarker group CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0021364
Disease: Male infertility
Male infertility 		0.330 Biomarker phenotype CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0848676
Disease: Subfertility, Male
Subfertility, Male 		0.300 Biomarker phenotype CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0917731
Disease: Male sterility
Male sterility 		0.300 Biomarker phenotype CTD_human Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. 8642790 1996
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.400 Biomarker disease CTD_human We examined whether the M235T polymorphism of the angiotensinogen (AGT) gene, the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene, and the A1166--> C polymorphism of the angiotensin II type 1 receptor gene may be associated with disease progression in 168 Caucasian patients with IgA nephropathy. 9259580 1997
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.400 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
CUI: C0948480
Disease: Coronary Restenosis
Coronary Restenosis 		0.360 Biomarker disease CTD_human D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. 9236417 1997
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.900 Biomarker disease CTD_human Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. 10643899 1999