Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The AFP levels were elevated in 8 cases of yolk sac tumor.
|
31627179 |
2020 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, tissue diagnosis and elevated alpha-fetoprotein (AFP) levels were suggestive of a YST.
|
31640397 |
2020 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It has been suggested that alpha-fetoprotein (AFP) can be applied as a feasible tumor marker because its level was elevated in >90% of YST.
|
31114774 |
2019 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The current study is a multi-faceted examination of yolk sac tumor-like phenotypes in endometrial tumors, based on an analysis of 3 groups of uterine tumors: Group 1: 9 endometrial tumors that had been classified as yolk sac tumor, or as having a yolk sac tumor component, were assessed with a 35-marker immunohistochemical panel, with the goal of defining their immunophenotypic spectrum; Group 2, comprised of 70 endometrial carcinomas of various histotypes, were analyzed for their expression of SALL4, Glypican-3, and AFP, to assess the specificity of these markers for yolk sac tumors relative to endometrial carcinomas; Group 3, comprised of 626 archived cases of endometrial carcinoma/carcinosarcoma, reviewed to define the frequency of yolk sac tumor-like morphology therein.
|
31375771 |
2019 |
Yolk Sac Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This 18-year-old woman underwent laparoscopic pelvic tumor resection, considered her first surgery, 2 years ago, and pathology revealed YST with initial alpha-fetoprotein (AFP) level measuring >3,000 ng/mL.
|
30992672 |
2019 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Coexpression of CAM5.2, SALL4, glypican-3, and AFP provides the best support for YST differentiation; however, it has to be noted that none of these markers is specific for these tumors and immunohistochemical results will always have to be interpreted in the context of morphologic, clinical, and radiologic information.
|
27643524 |
2019 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Primary endometrial YST is a very rare malignancy, and a primary endometrial YST in the absence of abnormal AFP levels is even rarer.
|
30985686 |
2019 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other markers had higher specificity for each cellular lineage; napsin-A and PAX8 were expressed only in CCC, while SALL4, villin, AFP and HepPar-1 were positive in the glandular YST component but negative in the clear cell component.
|
29106744 |
2018 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obviously elevated alpha fetoprotein (AFP) levels were detected in all the YSTs.
|
29705139 |
2018 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST).
|
29933751 |
2018 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alpha-fetoprotein (AFP) is a well-known tumor marker of hepatic carcinoma and yolk sac tumor.
|
29788728 |
2018 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The elevated serum AFP level and pathologcial examination confirmed mixed ovarian YST.
|
30113473 |
2018 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The intestinal-type mucinous glands were immunoreactive for SALL4 (4 cases), AFP (4 cases), glypican 3 (1 case), CDX2 (6 cases), and villin (7 cases), markers that are commonly expressed in YSTs, although the latter 2 markers would be expected to be positive in intestinal-type glands.
|
28582340 |
2018 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For germ cell tumors, the mean preoperative serum α-fetoprotein (AFP) level was significantly higher in patients with yolk sac tumor than in those with teratomas (2,078 ng/mL vs 5.7 ng/mL).
|
30324570 |
2018 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AFP levels were elevated in most malignant GCTs, markedly elevated in yolk sac tumors.All patients were treated surgically.
|
28658171 |
2017 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all patients, elevation of alpha-fetoprotein indicated a yolk sac tumor component.
|
28306215 |
2017 |
Yolk Sac Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Histopathology of surgically resected tissue revealed a mixture of adenocarcinoma and endodermal sinus tumor components with α-fetoprotein production.
|
27351795 |
2017 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Remarkably elevated α-fetoprotein (AFP) or human chorionic gonadotropin (hCG) was seen in cases with yolk sac tumour or choriocarcinoma, respectively.
|
27862157 |
2017 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The histology and elevation of α-fetoprotein were typical for a YST.
|
29113273 |
2017 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZBTB16 is a sensitive and specific marker for YST and is diagnostically superior to AFP and glypican-3 in metastatic and extragonadal settings.
|
28581124 |
2017 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
This proportion of patients is even lower for those with seminomas or pure embryonal carcinomas as alpha-fetoprotein is predominantly related to yolk sac tumor and human chorionic gonadotropin to choriocarcinoma.
|
24922631 |
2014 |
Yolk Sac Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed EPCAM expression by quantitative RT-PCR in 48 fresh-frozen GCT specimens of different histology (10 mature teratoma, MT; 6 immature teratoma, IT; 7 dysgerminoma; 6 mixed malignant GCTs; 19 yolk sac tumor, YST) and in the GCT cell lines NCCIT, TE76.T, JAR and 2102Ep, and correlated its expression with AFP and hCG protein levels, histologic differentiation, and clinical follow-up data.
|
22987628 |
2013 |
Yolk Sac Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cells were transplanted into the cheek pouch of hamsters and produced an endodermal sinus tumor. alpha-Fetoprotein subfractions in the conditioned media were studied by a modified method of lectin affinity crossed-line immunoelectrophoresis, and we found that the HAEST cells produced concanavalin A nonreactive subfraction, lentil lectin weakly reactive subfraction, phytohemagglutinin-E reactive subfraction and phytohemagglutinin-E nonreactive subfraction, which were predominantly synthesized by the fetal yolk sac, at an early stage of gestation.
|
2430863 |
1986 |
Yolk Sac Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In spite of variations of the AFP profile in cancer patients, in most cases it was possible to differentiate primary liver cancer from yolk sac tumour and from liver metastases of cancer.
|
6171874 |
1981 |