|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling.
|
31016362 |
2019 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling.
|
31016362 |
2019 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
To quantify hypertension-induced mutations, BigBlue<sup>®+/-</sup> rats, which carry a transgenic lacI gene for mutation analysis, were treated for 20 weeks with a mean dose of 400 µg angiotensin II/kg × day.
|
31098697 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
To quantify hypertension-induced mutations, BigBlue<sup>®+/-</sup> rats, which carry a transgenic lacI gene for mutation analysis, were treated for 20 weeks with a mean dose of 400 µg angiotensin II/kg × day.
|
31098697 |
2019 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Mitogen-activated protein kinase p38 target regenerating islet-derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart.
|
27798352 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats.
|
27225954 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Our results demonstrate that candesartan can ameliorate the arsenic-mediated systemic hypertension and vascular remodeling in rats by regularizing the signaling pathways of AngII and TGF-β.
|
27889505 |
2016 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats.
|
27225954 |
2016 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.
|
26781276 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Angiotensin II (490 ng·kg<sup>-1</sup>·min<sup>-1</sup>) or deoxycorticosterone acetate (DOCA) salt-induced mouse hypertensive models in genetic ablation, pharmacologic inhibition of CXCR2, and adoptive bone marrow transfer mice were used to determine the role of CXCR2 in hypertension (measured by radiotelemetry and tail-cuff system), inflammation (verified by flow cytometry and quantitative real-time polymerase chain reaction [PCR] analysis), vascular remodeling (studied by haematoxylin and eosin and Masson's trichrome staining), vascular dysfunction (assessed by aortic ring), and oxidative stress (indicated by nicotinamide adenine dinucleotide phosphate [NADPH] oxidase activity, dihydroethidium staining, and quantitative real-time PCR analysis).
|
27678262 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice.
|
26781276 |
2016 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Our results demonstrate that candesartan can ameliorate the arsenic-mediated systemic hypertension and vascular remodeling in rats by regularizing the signaling pathways of AngII and TGF-β.
|
27889505 |
2016 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Mitogen-activated protein kinase p38 target regenerating islet-derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart.
|
27798352 |
2016 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Angiotensin II (490 ng·kg<sup>-1</sup>·min<sup>-1</sup>) or deoxycorticosterone acetate (DOCA) salt-induced mouse hypertensive models in genetic ablation, pharmacologic inhibition of CXCR2, and adoptive bone marrow transfer mice were used to determine the role of CXCR2 in hypertension (measured by radiotelemetry and tail-cuff system), inflammation (verified by flow cytometry and quantitative real-time polymerase chain reaction [PCR] analysis), vascular remodeling (studied by haematoxylin and eosin and Masson's trichrome staining), vascular dysfunction (assessed by aortic ring), and oxidative stress (indicated by nicotinamide adenine dinucleotide phosphate [NADPH] oxidase activity, dihydroethidium staining, and quantitative real-time PCR analysis).
|
27678262 |
2016 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells.
|
25874449 |
2015 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines.
|
26564064 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.
|
25398788 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Rosiglitzone suppresses angiotensin II-induced production of KLF5 and cell proliferation in rat vascular smooth muscle cells.
|
25874449 |
2015 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.
|
25398788 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines.
|
26564064 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice.
|
24935938 |
2014 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice.
|
24935938 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase.
|
24347665 |
2014 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
We hypothesized that inhibition of angiotensin-converting enzyme (ACE) in the hypothalamic paraventricular nucleus (PVN) attenuates angiotensin II (ANG II)-induced hypertension via restoring neurotransmitters and cytokines.
|
24342267 |
2014 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.
|
25139994 |
2014 |