EN2, engrailed homeobox 2, 2020

N. diseases: 3; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.590 Biomarker disease CTD_human Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum. 25290267 2014
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease CTD_human Intronic single nucleotide polymorphisms of engrailed homeobox 2 modulate the disease vulnerability of autism in a han chinese population. 20523082 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease CTD_human Increased susceptibility to kainic acid-induced seizures in Engrailed-2 knockout mice. 19186208 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease CTD_human En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. 16935268 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.400 Biomarker disease CTD_human Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. 15024396 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET Our findings indicate that modulation of brain noradrenergic systems rescues the depression-related phenotype in En2−/− mice and suggest new roles for NE in the pathophysiology of the social and cognitive deficits seen in neuropsychiatric disorders such as autism or schizophrenia. 24730055 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET We found no significant association of schizophrenia with this bi-nucleotide repeat polymorphism of the EN2 gene. 15123388 2004