Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma.
|
31608140 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.
|
31100410 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, these results define the ERK-ETV5-RET pathway as a critical axis driving neuroblastoma oncogenesis downstream of activated ALK.
|
29321660 |
2018 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of MEK/ERK activity by AZD8055 confers acquired resistance in neuroblastoma.
|
29571732 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces β-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
|
30541014 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our previous study, both trametinib (MEK inhibitor) and CH5126766 (RAF/MEK inhibitor) showed in vitro antitumor effects on neuroblastoma cells with ERK phosphorylation (pERK).
|
30266481 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells.
|
29496180 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clearance of Damaged Mitochondria Through PINK1 Stabilization by JNK and ERK MAPK Signaling in Chlorpyrifos-Treated Neuroblastoma Cells.
|
26892626 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated the response of neuroblastoma cell lines to MEK-ERK pathway inhibition by trametinib.
|
29184034 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data reveal that cearoin induces autophagy, ERK activation and apoptosis in neuroblastoma SH-SY5Y cells, which is mediated primarily by ROS generation, suggesting its therapeutic application for the treatment of neuroblastomas.
|
28178193 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects.
|
26993602 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the amount of phosphorylation of the kinase ERK and neurite outgrowth increased upon Cbl-b depletion in several neuroblastoma cell lines.
|
25921289 |
2015 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, EGFR regulates Mcl(-)1 dependence in high-risk NB via ERK-mediated phosphorylation of Bim such that EGFR/ERK inhibition renders Mcl(-)1 dependent tumors now reliant on Bcl(-)2.
|
25756510 |
2015 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A cell-based assay was developed using natively expressed ORL-1 receptors on mouse neuroblastoma cells to measure phosphorylated ERK as a reporter of agonist-induced receptor activation and intracellular signaling.
|
25677767 |
2015 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified β-estradiol and MAPK/ERK as having functional cross-talk with MYCN and being novel targetable vulnerabilities of MYCN-amplified neuroblastoma.
|
26673823 |
2015 |
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells.
|
24550142 |
2014 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of ERK1 activity using pharmacologic inhibitors of mitogen-activated ERK kinase (MEK1/2) showed significant synergistic growth inhibitory activity when combined with GSK923295 in neuroblastoma, lung, pancreatic and colon carcinoma cell lines.
|
22948716 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells.
|
19241161 |
2009 |
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain.
|
18809477 |
2008 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results show that TGFalpha is a potent mitogen of neuroblastoma cells and suggest a connection between activation of ERK and Hes-1, thus providing a link between the Ras and Notch signaling pathways.
|
16120441 |
2005 |
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Remarkably knock-down of WOX1 expression by small interfering RNA in neuroblastoma SK-N-SH cells spontaneously induced Tau phosphorylation at Thr212/Thr231 and Ser515/Ser516, enhanced phosphorylation of glycogen synthase kinase 3beta (GSK-3beta) and ERK, and enhanced NFT formation.
|
15126504 |
2004 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SH-SY5Y neuroblastoma cells exposed to the complex I inhibitor/parkinsonian neurotoxin methylpyridinium ion (MPP(+)) activate both survival and death-promoting signaling pathways and undergo MEK/ERK-dependent, phosphatidylinositol-3 kinase-dependent, and c-Jun kinase-dependent cell death.
|
12710931 |
2003 |
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, several neuroblastoma cell lines with 1p deletion and one SCLC cell line express DRT transcripts of aberrant size (i.e.
|
8589679 |
1995 |