|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the methylation status in promoter region of estrogen receptor alpha (ERа)-A gene and its relation with plasma homocysteine (Hcy) level and cognitive impairment in white matter hyperintensity (WMH) patients.
|
30690641 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data indicate that ERα and ERβ are involved in the cognitive impairment in type 2 diabetes, and that activated ERs, such as application of ERs agonists, could be a novel and promising strategy for the treatment of diabetic cognitive impairment.
|
30201537 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic administration of oestrogen, progesterone, ER modulators/agonists or blockade of testosterone exhibited anti-inflammatory and antioxidant actions on single seizure-induced neuronal injury, while ER agonists additionally improved memory function and up-regulated CREB signalling and hippocampal GABA(A)α1 receptor density, suggesting that ERα or ERβ receptor activation may be beneficial in protecting against seizure-related oxidative brain injury and cognitive dysfunction.
|
31608530 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the estrogen receptor α (ERα)/silent mating type information regulation 2 homolog 1 (SIRT1)-dependent antioxidant efficacy of 17β-estradiol against d-gal-induced oxidative damage-mediated cognitive dysfunction in a male mouse model.
|
31430865 |
2019 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the estrogen receptor <i>ESR1</i> and <i>ESR2</i> genes have been linked with cognitive deficits and affective disorders.
|
30544539 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice.
|
30096284 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging.
|
28355325 |
2017 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we have provided a feasible new mechanism to explain the abnormal function of mossy fibers and cerebellar granule cells related to memory and cognitive decline in AD apart from the Tau and amyloid pathogenesis through our BARHL1-ESR1 axis.
|
28956815 |
2017 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several ESR1 polymorphisms were associated with cognitive decline as assessed by Chinese versions of Mini-Mental State Examination and Alzheimer Disease Association Scales-Cognitive Subscale.
|
23567436 |
2014 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant effect of ESR1 genotypes was observed for the donepezil-treated patients, among which those carrying at least one copy of P and X alleles showed a significantly lower cognitive decline than the noncarriers.
|
24150894 |
2014 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women.
|
23932494 |
2013 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The relationships between ESR1 and cognitive impairment tend to be specific to or driven by women and restricted to risk for Alzheimer disease rather than other dementia causes.
|
20616674 |
2010 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that among non-demented community elders, several SNPs in the ESR1 and ESR2 genes were associated with risk of developing cognitive impairment.
|
17889406 |
2009 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies' risk such as Alzheimer's disease (AD) or cognitive decline.
|
18342444 |
2008 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multifactorial models based on an exhaustive view of all hormonal events throughout the reproductive life (rather than on a specific exposure to a given steroid) together with other risk factors (notably genetic risk factors related to estrogen receptor polymorphisms) should be explored to clarify the role of hormonal risk factors, or protective factors for cognitive dysfunction and dementia.
|
18072983 |
2008 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ESR1 polymorphisms are also associated with a faster cognitive decline in the women AD patients.
|
16699281 |
2006 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hormone replacement therapy, age and executive cognitive ability were examined as covariates for ESR1 gene effects on cognitive impairment.
|
16538187 |
2006 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether estrogen receptor 1 (ESR1) polymorphisms are associated with risk of developing cognitive impairment in older women.
|
11955468 |
2002 |