ESR1, estrogen receptor 1, 2099

N. diseases: 1101; N. variants: 185
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE Three out of ten analyzed polymorphisms in the ESR1 gene (rs2234693, rs6902771, rs7774230) and one out of eight analyzed polymorphisms in the ESR2 gene (rs3020449) were associated with MS. 30049354 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 Biomarker disease BEFREE In conclusion, dietary supplementation of GSE attenuated features of metabolic syndrome partially through ERα-dependent mechanisms. 29740325 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE Associations of Estrogen Receptor Alpha Gene Polymorphisms with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Systematic Review and Meta-Analysis. 29883973 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 AlteredExpression disease BEFREE Moreover, reduced muscle ERα expression levels are observed in women and animals presenting clinical features of the metabolic syndrome (MetSyn). 30005878 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE The current study aimed to elucidate associations of MetS with ESR1 and ESR2 gene polymorphisms in postmenopausal Chinese women. 30217154 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 Biomarker disease BEFREE More recent evidence suggests that the effect of metabolic syndrome and diabetes is not the same for all subtypes of breast cancer with inferior disease-free survival and worse overall survival only found in women with ERα positive breast cancer and not for other subtypes. 26647383 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 Biomarker disease BEFREE Dietary supplementation of polyphenols remarkably attenuates features of metabolic syndrome; these effects are partially mediated by ERα-dependent mechanisms. 28119607 2016
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features. 26370976 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE ER α diplotypes and genotypes distributions were similar between participants with and without metabolic syndrome, in the overall group of subjects, and by gender. 24140101 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE The XbaI polymorphism of the estrogen receptor alpha gene is associated with metabolic syndrome. 23809427 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART. 22011627 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 Biomarker disease BEFREE Further investigation regarding the potential involvement of estrogen receptor genes and the metabolic syndrome may be warranted in other ethnic groups. 19032032 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE In this study, we examine the association of stroke with two common polymorphisms of the ESR1 gene in patients with metabolic syndrome. 17854418 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 Biomarker disease BEFREE Significant associations were detected between ESR1 SNPs and the metabolic syndrome (P = 0.005 to P = 0.029), type 2 diabetes (P = 0.001), insulin sensitivity (P = 0.0005 to P = 0.023), fasting insulin (P = 0.022 to P = 0.033), triglycerides (P = 0.021), LDL (P = 0.016 to P = 0.034), cholesterol (P = 0.046), BMI (P = 0.016 to P = 0.035), waist circumference (P = 0.012 to P = 0.023), and subcutaneous adipose tissue area (P = 0.016). 17513703 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.100 GeneticVariation disease BEFREE Selected ESR1 and ESR2 genotypes were associated with insulin sensitivity and metabolic syndrome only in Japanese and Chinese women. 16949391 2006