Disease: Autoimmune Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE Potential applications of Z<sub>FcRn</sub> as a general treatment modality for autoimmune diseases are discussed. 29572538 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE Inhibition of FcRn with rozanolixizumab may provide a novel therapeutic approach to reduce pathogenic IgG in human autoimmune disease. 30130439 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE Inhibition of FcRn is an attractive new treatment concept for IgG-mediated autoimmune diseases. 29093180 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE In contrast, some of the most important effector mechanisms relevant in therapy of autoimmunity are based on the Fc-portion of IgG; they include scavenging of complement and blockade/modulation of IgG receptors (Fc gamma receptor [FcγR] or the neonatal Fc receptor [FcRn]). 27019051 2016
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE In conclusion, FcRn is a common acceptor protein for internalization of AMA and, perhaps, for PV autoantibodies to other intracellular antigens, and PV is a novel disease paradigm for investigating and elucidating the role of FcRn in this autoimmune disease and possibly other autoimmune diseases. 26260795 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE In addition, designing inhibitors for FcRn-IgG interaction is another application prospect for treating IgG-mediated autoimmune diseases. 24404896 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE Studies on mouse models have indicated that the neonatal Fc receptor (FcRn) plays important roles in a variety of autoimmune diseases. 19772792 2009