|
Malignant neoplasm of pancreas
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the palladin gene was found to segregate with the disease in a family with a clear predisposition for pancreatic cancer, though this has yet to be found in other such kindreds.
|
19349734 |
2009 |
|
Malignant neoplasm of pancreas
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial.
|
19336541 |
2009 |
|
Malignant neoplasm of pancreas
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Mutations responsible for familial predisposition are mostly unknown, although BRCA2 mutations have been identified in some families and a mutation in the palladin gene has been shown to segregate with pancreatic cancer in one kindred.
|
18818508 |
2008 |
|
Malignant neoplasm of pancreas
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
However, caution must be used toward the palladin mutation, as several recent publications have questioned its significance as a pancreatic cancer causing mutation.
|
17992582 |
2008 |
|
Malignant neoplasm of pancreas
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of palladin relative to normal pancreas in the majority of pancreatic cancers is limited to non-neoplastic stromal cells.
|
17404500 |
2007 |
|
Malignant neoplasm of pancreas
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.
|
17415588 |
2007 |
|
Malignant neoplasm of pancreas
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
These observations suggest that the presence of an abnormal palladin gene in familial pancreatic cancer and the overexpression of palladin protein in sporadic pancreatic cancer cause cytoskeletal changes in pancreatic cancer and may be responsible for or contribute to the tumor's strong invasive and migratory abilities.
|
17194196 |
2006 |
|
Malignant neoplasm of pancreas
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Pancreatic Neoplasm
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have shown that the actin-binding protein palladin is highly expressed in the stroma of pancreas tumors, but the interpretation of these results is complicated by the fact that palladin exists as multiple isoforms.
|
26333695 |
2015 |
|
Pancreatic Neoplasm
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Isoform-specific upregulation of palladin in human and murine pancreas tumors.
|
20436683 |
2010 |
|
Pancreatic carcinoma, familial
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
|
19336541 |
2009 |
|
Pancreatic carcinoma, familial
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer.
|
17415588 |
2007 |
|
Pancreatic Neoplasm
|
0.330 |
AlteredExpression
|
disease |
LHGDN |
Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.
|
17194196 |
2006 |
|
Pancreatic carcinoma, familial
|
0.330 |
Biomarker
|
disease |
BEFREE |
These observations suggest that the presence of an abnormal palladin gene in familial pancreatic cancer and the overexpression of palladin protein in sporadic pancreatic cancer cause cytoskeletal changes in pancreatic cancer and may be responsible for or contribute to the tumor's strong invasive and migratory abilities.
|
17194196 |
2006 |
|
Pancreatic carcinoma, familial
|
0.330 |
SusceptibilityMutation
|
disease |
ORPHANET |
These observations suggest that the presence of an abnormal palladin gene in familial pancreatic cancer and the overexpression of palladin protein in sporadic pancreatic cancer cause cytoskeletal changes in pancreatic cancer and may be responsible for or contribute to the tumor's strong invasive and migratory abilities.
|
17194196 |
2006 |
|
Pancreatic Neoplasm
|
0.330 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
|
19030233 |
2008 |
|
Breast Carcinoma
|
0.120 |
Biomarker
|
disease |
BEFREE |
The identification of palladin as an Akt1-specific substrate in our recently published work has exemplified distinct Akt isoform-specific signaling in breast cancer.
|
21519185 |
2011 |
|
Breast Carcinoma
|
0.120 |
Biomarker
|
disease |
BEFREE |
These findings identify palladin as an Akt1-specific substrate that regulates cell motility and provide a molecular mechanism that accounts for the functional distinction between Akt isoforms in breast cancer cell signaling to cell migration.
|
20471940 |
2010 |
|
Breast Carcinoma
|
0.120 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant tumor of colon
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Gene expression array analysis on the poorly metastatic HCT116 colon cancer cell line and a metastatic derivative cell line (E1) with EMT (epithelial-mesenchymal transition) features showed a down-regulation of palladin gene expression in the latter.
|
20811713 |
2010 |
|
Malignant tumor of colon
|
0.110 |
Biomarker
|
disease |
HPO |
|
|
|
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |