Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Interestingly, the forced expression of NR4A3 induced only the GAP43 but not the other molecules involved in NB cell differentiation, such as MYCN, TRKA, and PHOX2B.
|
31183633 |
2019 |
Neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we validated the ability of 14 commonly used real-time RT-PCR markers to detect MRD based on their expression in neuroblastoma TICs, and we developed a novel MRD detection protocol, which scored the samples as MRD-positive when the expression of one of the 11 real-time RT-PCR markers (CHRNA3, CRMP1, DBH, DCX, DDC, GABRB3, GAP43, ISL1, KIF1A, PHOX2B and TH) exceeded the normal range.
|
23417100 |
2013 |
Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
We used embryonal carcinoma (EC) and neuroblastoma (NB) cell lines and found that lovastatin promoted apoptosis and induced expression of the neuronal differentiation markers, tyrosine hydroxylase (TH), and growth-associated protein 43.
|
20694854 |
2010 |
Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Here, neuroblastoma (NB) cell line subtypes were characterized according to embryonic peripheral nervous system development markers (GAP43, Phox2b, Sox10, c-kit, GD2, NF68, vimentin, S100beta, calcyclin and ABCG2), morphological features, gene expression and differentiation potential.
|
19216736 |
2009 |
Neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Whereas all neuroblastomas express growth-associated protein-43, neuropeptide tyrosine, and Bcl-2, tumors with differentiating cells with neuroendocrine features expressed these genes only in the morphologically immature, proliferating cells.
|
9006328 |
1997 |
Neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Genes selectively expressed in mature neurons (SCG-10, ret proto-oncogene, GAP-43, etc.) are transcriptionally activated, and neurite outgrowth further demonstrates differentiation of transfectants following NGF stimulation. trkA-expressing NB cells remain tumorigenic in nude mice; however, subcutaneous treatment of tumor-bearing mice with NGF induces Schwannian and neuronal cell differentiation similar to the induction seen in human ganglioneuroblastomas.
|
8246962 |
1993 |
Neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.
|
8477653 |
1993 |
Neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of neuromodulin (GAP-43) in mouse neuroblastoma clone N1E-115 as evaluated by the RT/PCR method.
|
1374507 |
1992 |