SH2B1, SH2B adaptor protein 1, 25970

N. diseases: 140; N. variants: 19
Disease: Retinoblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.020 AlteredExpression disease BEFREE Surprisingly, sustained PSM-RB expression impeded the proliferation of SiHa cells, resulting in both cell cycle inhibition and cell death. 18506774 2009
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.020 AlteredExpression disease BEFREE However, phosphorylation of the retinoblastoma tumor suppressor protein (RB) is still required for G1-S progression in androgen-independent cells, since the expression of constitutively active RB (PSM-RB) or p16ink4a caused cell cycle arrest and mimicked the effects of androgen withdrawal on downstream targets in androgen-dependent LNCaP cells. 10939590 2000