PHGDH, phosphoglycerate dehydrogenase, 26227

N. diseases: 288; N. variants: 33
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.340 GeneticVariation disease BEFREE Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. 31331318 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.340 AlteredExpression disease BEFREE Here, we demonstrate that increased PHGDH expression promotes tumor progression in mouse models of melanoma and breast cancer, human tumor types that exhibit PHGDH copy-number gain. 30905671 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE Recent evidence has shown that PHGDH is amplified in human breast cancer and melanoma and plays a key role in cancer metabolism. 23229761 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE PHGDH amplification and altered glucose metabolism in human melanoma. 21981974 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease CTD_human An analysis of human cancers showed that PHGDH is recurrently amplified in a genomic region of focal copy number gain most commonly found in melanoma. 21804546 2011