|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acromegaly, a condition traditionally characterized by increased levels of growth hormone secretion as a result of pituitary adenoma, results in increased tissue growth, lipolysis, and can result in patients with hyperglycemia and hyperinsulinemia.
|
31071497 |
2020 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we review this mouse model in terms of its ability to allow comparison of hGH versus mGH gene expression, and specifically: (i) GH locus structure as well as regulated and rhythmic expression; (ii) their ability to model a clinical assessment of hGH production in response to overeating and hyperinsulinemia as well as a possible effect of exercise, and (iii) their hGH-related immune tolerance and thus potential for testing hGH-related analogue immunogenicity.
|
30227383 |
2019 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Growth hormone replacement therapy partially increased his blood glucose levels, but asymptomatic hypoglycemia with hyperinsulinemia was occasionally noticed.
|
29355723 |
2018 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth hormone, IGF1, and hyperinsulinemia are associated with increased risk of growth progression of some cancer types.
|
28316059 |
2017 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reduced serum IGF-1 levels in the bGH mice did not alleviate the hyperinsulinemia and did not resolve liver or kidney pathologies that resulted from GH hypersecretion.
|
28475811 |
2017 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Animals exposed to 3 days of high caloric intake exhibited hyperinsulinemia without hyperglycemia and a decrease in both hGH synthesis and secretion, but no difference in endogenous production of murine GH.
|
25295535 |
2014 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin, growth hormone and TNFα all diminished expression of adipoR2 in adipocytes and adipoR1 in myotubes, while insulin increased the expression of adipoR2 in the muscle cells.
|
22442376 |
2012 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other mechanisms by which the brain regulates adipose tissue and beta cells of the pancreas include the sympathetic nervous system, vagally mediated hyperinsulinemia and the endocrine system, namely growth hormone, thyroid-stimulating hormone and the hypothalamo-pituitary-adrenal axis.
|
19955767 |
2010 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that mechanisms linking GH deficiency and GH resistance with delayed aging include reduced hepatic synthesis of insulin-like growth factor 1 (IGF-1), reduced secretion of insulin, increased hepatic sensitivity to insulin actions, reduced plasma glucose, reduced generation of reactive oxygen species, improved antioxidant defenses, increased resistance to oxidative stress, and reduced oxidative damage.
|
15536017 |
2004 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human placental growth hormone causes insulin resistance as manifested by fasting and postprandial hyperinsulinemia and minimal glucose lowering in response to insulin injection.
|
11904616 |
2002 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These abnormalities include low growth hormone levels in response to provocative stimuli, delayed puberty associated with prepubertal levels of gonadotropins in the males and pubertal levels of gonadotropins in the females, type II diabetes mellitus with elevated insulin levels, mild mental retardation, sensori-neural deafness, and alopecia without pili torti.
|
1442893 |
1992 |