|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, in RCC the Cx32 gene is silenced by hypermethylation of CpG islands in a promoter region of the Cx gene.
|
24335094 |
2013 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the restoration of Cx32 by 5-Aza pre-treatment improves chemical tolerance on VBL in Caki-1 cells and that the JNK activation is a key factor to induce the effect.
|
20510207 |
2010 |
|
Renal Cell Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we used human metastatic RCC cell (Caki-1), and established Cx32-expressed cell clone (Caki-1T) or only mock-transfected cell clone (Caki-1W).
|
18058801 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding suggests that treatment with 5-aza-CdR could be a new effective therapy against human metastatic RCC and that Cx32 could be a potential target for the treatment of RCC.
|
18264126 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
In this study, we used human metastatic RCC cell (Caki-1), and established Cx32-expressed cell clone (Caki-1T) or only mock-transfected cell clone (Caki-1W).
|
18058801 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
This finding suggests that treatment with 5-aza-CdR could be a new effective therapy against human metastatic RCC and that Cx32 could be a potential target for the treatment of RCC.
|
18264126 |
2008 |
|
Renal Cell Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have previously reported that Cx32 is specifically downregulated in human renal cell carcinoma (RCC) cell lines as well as cancerous regions when compared to normal regions in kidneys.
|
17565422 |
2007 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, we briefly summarize the tumor-suppressive effects of Cx genes, refer to a new aspect of Cx32 as an anti-invasive and anti-metastatic gene against renal cell carcinoma in a GJIC-independent function and establishment of a new cancer therapy based on the new function of Cx32.
|
17015938 |
2006 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In line with the previous study, here we examined if a Src family inhibitor (PP1) could potentiate tumor-suppressive effect of Cx32 in Caki-2 cell from human renal cell carcinoma.
|
15792837 |
2005 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma.
|
15699574 |
2005 |
|
Renal Cell Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we investigated the clinical significance of methylation-dependent silencing of Cx32 gene in the development of the RCC from the hemodialysis patients.
|
15142671 |
2004 |
|
Renal Cell Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that hypermethylation in the promoter region is a mechanism for the Cx32 gene repression in the RCC cell.
|
12690227 |
2003 |