|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Administrtation of sh-NEAT1 also inhibited tumor growth <i>in vivo</i>, increased the miRNA-126 level and down-regulated VEGFA.
|
31585904 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of NEAT1 on tumor growth was observed in a mice model of transplanted hepatoma.
|
31819522 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo experiment further validated the inhibitory effects of NEAT1 knockdown on xenograft tumour growth.
|
30407674 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NEAT1 knockdown repressed tumor growth <i>in vitro</i> and <i>in vivo</i>.
|
30900419 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effects of lncRNA NEAT1 on tumor growth were further testified through glioma xenografts in nude mice.
|
30515782 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It indicated that overexpressed NEAT1 restrained the damage of RAI to tumor in both macroscopic and microcosmic.
|
30596336 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the role and mechanism of NEAT1 in RB were further evaluated in a mouse xenograft tumor model.
|
30479013 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of NEAT1 transcripts as well as transcripts encoding PSPC1, NONO, and RBM14 was increased in tumour tissue.
|
30946555 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, NEAT1 knockdown inhibited tumor growth, increased miR-497-5p expression, and decreased PIK3R1 expression in xenograft model mice compared with the negative control.
|
31486491 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicated that NEAT1 could function as a tumor oncogene in OS by inhibiting miR-339-5p in vitro.
|
30203547 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Repression of NEAT1 suppressed tumor growth in HCC mice.
|
30710754 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, our data revealed that HIF-1α was a downstream target of miR-186-5p and that NEAT1 could exert its tumor oncogenic roles on OS cells via the miR-186-5p/HIF-1α axis.
|
30485482 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Silencing of NEAT1 in HCC cells facilitated Sora sensitivity by enhancing drug-induced apoptosis, and led to smaller tumor size on nude mice.
|
30937906 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, knockdown and overexpression of NEAT1 suppressed and promoted tumor growth in the HCC mouse model, which were abolished by the miRNA-22-3p inhibitor and mimic, respectively.
|
31802908 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes.
|
31287002 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NEAT1 is an important tumor oncogenic gene in various tumors.
|
30932200 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The progressive emergence of the ERα and ERα-regulated genes (eg, progesterone receptor (PR), PS2, TMPRSS2-ERG fusion, and NEAT1) during prostate cancer progression and hormone refractory disease suggests that these tumors can bypass the AR by using estrogens and progestins for their growth.
|
29094395 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the regulation effect of NEAT1 on tumor formation was explored in vivo.
|
30338809 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we highlight the latest insights into the expression pattern, biological roles and mechanisms underlying the function and regulation of NEAT1 in tumors, and especially focus on its clinical implication as a new diagnostic biomarker and an attractive therapeutic target for cancers.
|
30374364 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo experiments, silence of lncRNA NEAT1 restrain tumor growth in weight and volume.
|
29319165 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft tumor assay was done to elucidate the role of NEAT1 involved in NPC tumor growth in vivo.
|
29565706 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NEAT1 knockdown cells produced smaller tumors, demonstrating that NEAT1 promotes tumor growth in vivo.
|
28810932 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of NEAT1 decreased the CSC-like properties of A549/CDDP cells through inhibiting tumor cell sphere volume, repressing CSC-like biomarkers levels and restraining CD44 positive cell ratios.
|
30291867 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of miR‑365 was decreased in OSCC tissues and inversely correlated with NEAT1 in tumors.
|
29484420 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via <i>miR-34c</i> The results <i>in vivo</i> also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS.
|
29654165 |
2018 |