Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
And rescue assays demonstrated that NEAT1 promotes HCC autophagy through modulating miR-204/ATG3 pathway.
|
31549407 |
2020 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the role of lncRNA nuclear enriched abundant transcript 1_2 (NEAT1_2) in radioresistance of HCC and its molecular mechanism in this study.
|
30488993 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since data on NEAT1 in HCC chemosensitivity are completely lacking and chemoresistance is linked to poor prognosis, we aimed to study NEAT1 expression in HCC chemoresistance and its link to HCC prognosis.
|
30946555 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of down-regulation or up-regulation of NEAT1 expression in HCC cell lines were analysed from the perspectives of cell viability and apoptosis.
|
31819522 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NEAT1 was elevated in HCC tissues and cell lines.
|
31819486 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Relative NEAT1 expression level was significantly increased in serum of HCC patients 4.7 (1.31-6.82) (p < .0001).
|
31190421 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA NEAT1 suppresses sorafenib sensitivity of hepatocellular carcinoma cells via regulating miR-335-c-Met.
|
30937906 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NEAT1 and Tim-3 were up-regulated in the PBMCs of patients with HCC (n = 20) compared with healthy subjects (n = 20).
|
30710754 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that NEAT1 expression was associated with tumor size and differentiation where NEAT1 was upregulated in both HCC tissues and cell lines.
|
31802908 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that NEAT1 was greatly upregulated in human HCC cell lines including Huh7, Hep3B, HepG2, Bel-7404, and SK-Hep1 cells compared to the normal human liver cell line LO2.
|
29219178 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both NEAT1 and NONO expression increase in human hepatocellular carcinoma (HCC) samples according to TCGA data.
|
30377567 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, NEAT1 downregulation can restrain HCC cell growth, migration, and invasion.
|
29797561 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of NEAT1 notably accelerated HCC cell proliferation, migration, and invasion.
|
30346062 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
|
30068940 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that the NEAT1 was high expression in HCC.
|
29091312 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also assessed the effects of ATGL, DAG, FFA, and NEAT1 on HCC cells proliferation in vitro and in an orthotopic xenograft HCC mouse model.
|
29764424 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pooled standard mean deviation (SMD) indicated that NEAT1 was up-regulated in HCC (SMD = 0.54; 95% CI, 0.36-0.73; P < 0.0001).
|
30021196 |
2018 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The pooled standard mean deviation (SMD) indicated that NEAT1 was down-regulated in esophageal carcinoma (ESCA, SMD = -0.35, 95% CI: -0.5~-0.20, P < 0.0001) and hepatocellular carcinoma (HCC, SMD = -0.47, 95% CI: -0.60~-0.34, P < 0.0001), while in pancreatic cancer (PC), NEAT1 was up-regulated (SMD = 0.45, 95% CI: 0.2~0.71, P = 0.001).
|
28118609 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Long non-coding RNA NEAT1 overexpression is associated with unfavorable prognosis in patients with hepatocellular carcinoma after hepatectomy: A Chinese population-based study.
|
28732670 |
2017 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the <i>NEAT1-hnRNP A2</i> regulation mechanism promotes HCC pathogenesis and may provide a potential target for the prognosis and treatment of HCC.
|
28260918 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, it was concluded that the expression of NEAT1 was significantly increased in the HCC tissues and cell lines.
|
28526689 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher NEAT1 expression associated with larger tumor size and vascular invasion of HCC patients.
|
28783584 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of NEAT1 promoted the clinical features of HCC, including the number of tumor nodes, metastasis, clinical TNM stage, the status of portal vein tumor embolus, vaso-invasion and the infiltration of tumor cells.
|
26191242 |
2015 |