GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Disease: Adult Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 Biomarker disease BEFREE HMGB1-Induced p62 Overexpression Promotes Snail-Mediated Epithelial-Mesenchymal Transition in Glioblastoma Cells via the Degradation of GSK-3β. 31037147 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 Biomarker disease BEFREE Furthermore, we proved that sortilin promoted cell invasion mainly via Glycogen synthase kinase 3 beta (GSK-3β)/β-catenin/Twist-induced EMT-like mesenchymal transition in glioblastoma. 30814514 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 AlteredExpression disease BEFREE Moreover, glycogen synthase kinase-3β (GSK-3β), an intact complex of E2F1, were also highly expressed in astrocytomas and linked with astrocytomas progression and poor prognosis of patients with astrocytomas and glioblastoma. 28042322 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 Biomarker disease BEFREE Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma. 28423558 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 AlteredExpression disease BEFREE Whilst p53 activation affects cell survival in response to TPEN, GSK-3β inactivation directly affects glioblastoma cell migration. 27654922 2016
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 Biomarker disease BEFREE Glioblastoma tissues from patients treated with the GSK3β-inhibiting drugs were subjected to immunohistochemistry and methylation-specific PCR assay. 23715499 2013
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.070 Biomarker disease BEFREE In short, we established a model to demonstrate that GSK3b interacts with and phosphorylates BCL2L12 and might also affect BCL2L12A to modulate the apoptosis signaling pathway in glioblastoma. 22262180 2012