H2AX, H2A.X variant histone, 3014

N. diseases: 212; N. variants: 6
Disease: Polyploidy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032578
Disease: Polyploidy
Polyploidy 		0.300 Biomarker phenotype CTD_human Since increased chromosomal damage resulted in extensive H2AX phosphorylation during polyploidy, we propose that the additional γ-H2AX during polyploidy incurred by carbon-ion radiation provides a final opportunity for these dangerous and chromosomally unstable cells to be eliminated. 25123929 2014