HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Disease: Memory impairment ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.030 Biomarker phenotype BEFREE Transduction of SUMO-modified lenti-HDAC1 vector to the hippocampus of APP/PS1 mice rescues spatial learning and memory deficit and long-term potentiation impairment in APP/PS1 mice. 28186506 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.030 GeneticVariation phenotype BEFREE We tested zinc-dependent HDACs using RNAi in Drosophila melanogaster and found memory deficits with RPD3 and HDAC6. 28178513 2017
CUI: C0233794
Disease: Memory impairment
Memory impairment 		0.030 AlteredExpression phenotype BEFREE Valproic acid is able to attenuate the prenatal hypoxia-induced Aβ neuropathology and learning and memory deficits via inhibiting the activation of histone deacetylase 1 (HDAC1), preventing the decrease in H3-Ace in the NEP promoter regions and reducing the down-regulation of NEP. 24289518 2014