Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The identification of HIF1A targets expressed in both normoxia and hypoxia and of HIF1A/hypoxia signatures might meliorate the prognostic stratification and therapeutic successes in patients with high-risk solid tumors.
|
30808328 |
2019 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Co-expression of HIF-1α, MDR1 and LAPTM4B in peripheral blood of solid tumors.
|
30746305 |
2019 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Characterization of the metabolic intermediates and the corresponding metabolic pathways altered by HIF-1α would facilitate the identification of therapeutic targets for hypoxic microenvironments prevalent in pancreatic ductal adenocarcinoma and other solid tumors.
|
29330793 |
2018 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The adaptation of solid tumors to the low oxygen/nutrient environment is mediated by the pivotal transcription role of hypoxia-inducible factor-1 (HIF-1).
|
29960020 |
2018 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
HIF-1α expression has been implied as an indicator of worse prognosis in various solid tumors.
|
28404916 |
2017 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The HIF-1 level is often upregulated in the hypoxic microenvironment of solid tumors, which contributes to cancer treatment failure.
|
27994464 |
2017 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Long-standing evidence suggests that one isotype of HIF, HIF-1α, is involved in the pathogenesis of various solid tumors and cardiac diseases.
|
28289375 |
2017 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review, we discuss the distinct and overlapping roles of HIF-1 and Nrf2 in the cellular response to hypoxia, with a focus on how targeting Nrf2 could provide novel chemotherapeutic modalities for treating solid tumors.
|
28383481 |
2017 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we evaluated the effect of HS-1793 on hypoxia-inducible factor-1α (HIF-1α), which drives angiogenesis and the growth of solid tumors, in addition to the in vivo therapeutic effects of HS-1793 on breast cancer cells.
|
28656256 |
2017 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Potential implication and application of the stress-facilitated HIF-1 activation in solid tumors and ischemic disorders will be discussed.
|
26206147 |
2016 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The increased expression of HIF-1α in most solid tumors is associated with poor prognoses and therapeutic outcomes.
|
26882240 |
2016 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hypoxia inducible factor-1α (HIF-1α) is overexpressed in various types of solid tumor in humans, including bladder cancer.
|
25824695 |
2015 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human breast and endometrial cancers.
|
25884381 |
2015 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the function of hypoxia-inducible factor 1 (HIF1) in many kinds of solid tumor has been revealed, the significance of HIF1 in osteosarcoma is still controversial and not well understood.
|
26077139 |
2015 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis.
|
24894671 |
2014 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hypoxia-inducible factor-1 (HIF-1) is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia, a common feature of the microenvironment in solid tumors.
|
24916276 |
2014 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This work suggests that mitochondria-targeting metabolic modulators that increase pyruvate dehydrogenase activity, in addition to the recently described pro-apoptotic and anti-proliferative effects, suppress angiogenesis as well, normalizing the pseudo-hypoxic signals that lead to normoxic HIF1α activation in solid tumors.
|
22614004 |
2013 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The HIF1- and HIF2-mediated transcriptional responses play critical roles in solid tumor progression.
|
23991099 |
2013 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors.
|
22678117 |
2012 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Deregulated accumulation of hypoxia-inducible factor-1α (HIF-1α) is a hallmark of many solid tumors.
|
22190738 |
2012 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF1α protein is associated with hypoxia response and neovascularization, essential conditions for solid tumors survival.
|
23028863 |
2012 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results revealed that Nox4 was predominantly highly expressed in the endogenous cycling hypoxic areas with HIF-1 activation and blood perfusion within the solid tumor microenvironment.
|
22713363 |
2012 |
Solid Neoplasm
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
HIF-1 is the key cellular survival protein under hypoxia, and is associated with tumor progression and metastasis in various solid tumors.
|
20627616 |
2011 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hypoxia is the hallmark of solid tumors and contributes to tumor angiogenesis mainly through activation of the transcription factor hypoxia-inducible factor-1 (HIF-1).
|
21048308 |
2010 |
Solid Neoplasm
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Another common feature of solid tumors is the presence of hypoxia as indicated by the up-regulation of hypoxia-inducible factors (HIFs) such as HIF-1α.
|
20844082 |
2010 |