Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, it is highly expressed and secreted in chemoresistant OVCA cells than its chemosensitive counterparts. pGSN, secreted and transported via exosomes (Ex-pGSN), upregulates HIF1α-mediated pGSN expression in chemoresistant OVCA cells in an autocrine manner as well as confers cisplatin resistance in otherwise chemosensitive OVCA cells.
|
31700155 |
2020 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer.
|
31639424 |
2020 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As determined by flow cytometry, immunofluorescence, RT-PCR, and western blots, there were higher expressions of CX3CR1 and HIF-1α in OvCa cell lines exposed to hypoxia.
|
31077234 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
<strong>CONCLUSIONS</strong> This study suggests that HIF-1alpha promotes ovarian cancer cell invasion through a MMP13 mechanism.
|
31587013 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
LINK-A Long Non-Coding RNA (lncRNA) Participates in Metastasis of Ovarian Carcinoma and Upregulates Hypoxia-Inducible Factor 1 (HIF1α).
|
30912527 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to investigate whether pharmacokinetic dynamic contrast-enhanced (DCE) perfusion parameters are associated with a specific marker of hypoxia, hypoxia-inducible factor 1 alpha (HIF-1α) in ovarian cancer (OC).
|
31437208 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Targeting HDAC4, HIF-1α and CREBZF may be considered in treatment of ovarian cancer with p53 and RAS mutations.
|
30867818 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia-inducible factor 1alpha (HIF-1alpha), one of the best-studied oncogenes, plays an important part in tumor adaptation to microenvironmental hypoxia and was found to be overexpressed in several malignancies, including ovarian cancer.
|
31175269 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Disruption of HIF1α-driven IL-8 signaling in mesothelial cells by metformin results in reduced OvCa invasion in an organotypic 3D model.
|
31851935 |
2019 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined the effects of SB on HIF-1α expression in ovarian cancer (OC) cell lines grown under normoxic and hypoxic conditions.
|
29797601 |
2018 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HIF-1α binding to AEG-1 promoter induced upregulated AEG-1 expression associated with metastasis in ovarian cancer.
|
28401704 |
2017 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results hinted that HIF1α and SIRT1 might serve as potential therapeutic targets for ovarian cancer.
|
28878214 |
2017 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggests that 20(S)-Rg3 is a strong inhibitor of hypoxia-inducible factor 1α, which may provide a novel agent for future treatments for ovarian cancer.
|
28459376 |
2017 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that the HIF-1α-regulated cancer metabolism pathway could be a novel target for overcoming cisplatin resistance in ovarian cancer.
|
26801746 |
2016 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.
|
26548925 |
2015 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HIF‑1α was suggested to be able to suppress the expression of E‑cadherin by upregulating Snail, thus serving an important role in invasion and metastasis of ovarian cancer.
|
25975373 |
2015 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypoxia-inducible factor-1 (HIF-1) is one of the most promising pharmacological targets for all types of cancer, including ovarian cancer.
|
25756515 |
2015 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1α pathway in human ovarian cancer in vitro.
|
25491408 |
2014 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that ROS play an important role in the initiation of metastatic growth of OC cells and support a molecular pathway from ROS to aggressive transformation which involves upregulation of HIF-1α and its downstream target LOX to suppress E-cadherin expression leading to an increase in cell motility and invasiveness.
|
25174950 |
2014 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis, providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1α pathways.
|
23389731 |
2013 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vitro, the effects of ABZ on HIF-1alpha levels in human ovarian cancer cells (OVCAR-3) were investigated using hypoxic chamber or desferrioxamine (DFO) induced-hypoxia.
|
20398289 |
2010 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that OPN can increase the survival of ovarian cancer cells under stress conditions in vitro and promote the late progression of ovarian cancer in vivo, and the survival-promoting functions of OPN are mediated through Akt activation and the induction of HIF-1alpha expression.
|
19016748 |
2008 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HIF-1 alpha expression in serous ovarian carcinoma was not stage dependent.
|
19014607 |
2008 |
Malignant neoplasm of ovary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular Endothelial Growth Factor (VEGF) and its transcriptional regulator Hypoxia-inducible Factor 1 (HIF-1) play an important role in the process of angiogenesis in many types of cancer, including ovarian cancer.
|
17498666 |
2007 |
Malignant neoplasm of ovary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To address this hypothesis, we first examined in vivo the immunohistochemical expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and its topological correlation with E-cadherin expression in ovarian carcinomas.
|
14507651 |
2003 |