|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes.
|
29924134 |
2018 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The development of drugs that specifically target 5-HT2C receptors will allow for better understanding of their involvement in the pathophysiology of psychiatric disorders including schizophrenia, anxiety, and depression.
|
26739950 |
2016 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability.
|
25732952 |
2015 |
|
Mental disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We previously revealed the altered mRNA expression and RNA editing of HTR2C in the postmortem brains of patients with mental disorders.
|
20015120 |
2010 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we overviewed the genetic, expression and RNA editing studies suggesting the close relationship between HTR2C and major mental disorders including schizophrenia, bipolar disorder and major depression.
|
19411841 |
2009 |
|
Mental disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The biological relevance of these brain structures is reviewed by way of the focus on HTR2C activity, with a special attention paid to psychiatric disorders.
|
18802918 |
2009 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Studies in humans have reported abnormalities in patterns of HTR2C editing in psychiatric disorders, and studies in rodents show altered patterns of editing in response to drug treatments and stressful situations.
|
17307311 |
2007 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To find informative gene variations, we have also compared the effects of some polymorphisms of the serotonin receptor 2C and 2A in mental disorders, for antipsychotic therapeutic effect, for antipsychotic neuronal side effects, and for obesity.
|
17168843 |
2006 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The importance of serotonin 2C receptor (HTR2C) in mental disorders has been implicated by studies of HTR2C-deficient mice and linkage and association studies.
|
12853111 |
2003 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, subjects who had committed suicide (regardless of diagnosis) exhibited a statistically significant elevation of editing at the A-site, which is predicted to change the amino acid sequence in the second intracellular loop of the 5-HT(2C)R. These findings suggest that alterations in RNA editing may contribute to or complicate therapy in certain psychiatric disorders.
|
11282248 |
2001 |
|
Mental disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There is a common polymorphism of the human 5-HT2C receptor at codon 23 (cys23ser) which has been reported to be a risk factor for certain psychiatric disorders and a predictor of their pharmacotherapeutic response.
|
10412190 |
1999 |