IFNGR1, interferon gamma receptor 1, 3459

N. diseases: 153; N. variants: 30
Disease: Post-kala-azar dermal leishmaniasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032749
Disease: Post-kala-azar dermal leishmaniasis
Post-kala-azar dermal leishmaniasis 		0.040 AlteredExpression disease BEFREE This study aimed to identify putative functional polymorphisms in the IFNGR1 gene, and to determine whether differences in expression of interferon-γ (IFNG) and IFNGR1 at the RNA level are associated with pathogenesis of VL and/or PKDL in Sudan. 25466928 2014
CUI: C0032749
Disease: Post-kala-azar dermal leishmaniasis
Post-kala-azar dermal leishmaniasis 		0.040 GeneticVariation disease BEFREE IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan. 17136124 2007
CUI: C0032749
Disease: Post-kala-azar dermal leishmaniasis
Post-kala-azar dermal leishmaniasis 		0.040 AlteredExpression disease BEFREE Therefore, unfavorable clinical evolution in PKDL may not be due to the absence of an intralesional Th1 response but rather may be due to the presence of counteracting cytokines along with the down-modulation of IFN-gamma R1. 16960784 2006
CUI: C0032749
Disease: Post-kala-azar dermal leishmaniasis
Post-kala-azar dermal leishmaniasis 		0.040 Biomarker disease BEFREE Hence, polymorphism in a type 2 cytokine gene influences underlying susceptibility to VL, whereas IFNGR1 is specifically related to susceptibility to PKDL. 12847550 2003