|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Emerging data suggest that interferon gamma (IFNG) and its receptor IFNGR1 may be involved in the risk of TB.
|
31310896 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon-gamma (IFNG) and its receptor (IFNGR1) are principal genes that associated with tuberculosis.
|
29228700 |
2017 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several studies have shown that susceptibility to tuberculosis may be associated with IFNGR1 gene polymorphisms.
|
29209098 |
2017 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present results revealed that certain genetic variants in IFNGR genes may be associated with TB development, which may be useful preliminary data for future investigation.
|
25815589 |
2015 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After the Bonferroni correction for multiple comparisons, three SNPs (rs2234711, rs1327475 and rs7749390) in IFNGR1 gene were observed to be significantly associated with the altered risks of tuberculosis.
|
24680779 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis did not provide enough powerful evidence to identify a significant association between IFNGR1 -56C/T polymorphism and TB susceptibility in the overall population.
|
25382336 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differences that were not statistically significant were found between the group of children with TB and the control group for the allelic markers (170 and 180) in the IFN-gammaR1 gene.
|
20055726 |
2010 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data implied the involvement of the ifngr1 gene in susceptibility to tuberculosis.
|
20500698 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that NOS2A variants may contribute to TB susceptibility, particularly in individuals of African descent, and may act synergistically with SNPs in TLR4 and IFNGR1.
|
19575238 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interferon gamma receptor 1 gene polymorphism in patients with tuberculosis in China.
|
18702743 |
2008 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
This is the first report of an association between TB and TNFR1 in a human population and our findings for IL-10 and IFNGR1 replicate previous findings.
|
17431682 |
2007 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Using reporter gene analysis of 5' deletion constructs of the IFN-gammaR1 gene (IFNGR1) promoter, the decrease in IFN-gammaR1 mRNA in M. tuberculosis-infected pdTHP-1 cells was shown to be due to the decreased transcription of IFNGR1.
|
17339358 |
2007 |
|
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Similar down modulation of IFN-gammaR1 protein and mRNA expression in phorbol myristate acetate-differentiated THP-1 cells (pdTHP-1) by M. tuberculosis was observed (P < 0.01).
|
17339358 |
2007 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first report of an association between TB and TNFR1 in a human population and our findings for IL-10 and IFNGR1 replicate previous findings.
|
17431682 |
2007 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and non-tuberculous mycobacterial lung diseases.
|
17023216 |
2007 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The disease association with IFNGR1 is novel, and together these findings support the hypothesis that genetically determined variation in both IFN-gamma production and responsiveness influences the risk of developing tuberculosis.
|
16690980 |
2006 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The disease association with IFNGR1 is novel, and together these findings support the hypothesis that genetically determined variation in both IFN-gamma production and responsiveness influences the risk of developing tuberculosis.
|
16690980 |
2006 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that a particular combination of IFNG and IFNGR1 SNP might offer a better protection against tuberculosis in this population.
|
16476014 |
2006 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated functional responsiveness to IFN-gamma in monocytes from patients with clinical TB (n = 10), and analysed the genetic sequences of the IFN-gamma receptor 1 (IFN-gammaR1) and STAT1 genes in patients with disseminated TB (n = 18).
|
15527154 |
2004 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between the IFNGR1 variants studied and TB in this Gambian population sample.
|
15047947 |
2004 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, our results also suggest that unidentified allelic variations in the IFNGR1 gene might elevate or decrease the risk in this ethnic population, as a part of the multigenic predisposition to tuberculosis.
|
12753505 |
2003 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
However, our results also suggest that unidentified allelic variations in the IFNGR1 gene might elevate or decrease the risk in this ethnic population, as a part of the multigenic predisposition to tuberculosis.
|
12753505 |
2003 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, whereas complete IFNgammaR1 deficiency in previously identified kindreds caused fatal lepromatoid BCG infection and disseminated NTM infection, partial IFNgammaR1 deficiency in this kindred caused curable tuberculoid BCG infection and clinical tuberculosis.
|
9389728 |
1997 |