IGF1R, insulin like growth factor 1 receptor, 3480

N. diseases: 556; N. variants: 92
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.220 GeneticVariation disease BEFREE We conclude that the common IGF-IR gene polymorphism G1013A modulates the risk of obesity for EADC, an effect most likely mediated by altered the receptor function by influencing gene transcription or mRNA stability. 19679045 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.220 GeneticVariation disease BEFREE Using quantitative PCR, we studied IGF-IR mRNA expression in 52 well-characterized surgically resected EADC and matched histologically normal esophageal tissues, and examined IGF-IR expression levels in relation to clinicopathologic characteristics, body mass index (BMI), and the common IGF-IR polymorphism (G1013A), recently proposed to modify risk of obesity for EADC. 19582762 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.220 Biomarker disease RGD IGF-I receptor mRNA levels were significantly reduced in obese rat hearts. 11009458 2000