|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downregulation of lncRNA SNHG12 reversed IGF1R-induced osteosarcoma metastasis and proliferation by targeting miR-195-5p.
|
31743769 |
2020 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the function of Let-7b in OS and clarify the regulation of insulin-like growth factor 1 receptor (IGF1R) by Let-7b.
|
30675224 |
2019 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, insulin‑like growth factor 1 receptor (IGF‑1R) was characterized as direct target gene of miR‑939 in OS.
|
31545400 |
2019 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the knockdown IGF-1R mimicked the functions of miR-302a overexpression on osteosarcoma cell migration and invasion.
|
29563995 |
2018 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the expression levels of IGF-1R were inversely correlated to the miR-503 levels in osteosarcoma tissues, suggesting that the increased IGF-1R expression may be caused by the reduced expression of miR-503.
|
28810619 |
2017 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma.
|
28643781 |
2017 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that targeting IGF1R by GSK1904529A inhibits OS cell growth in vitro and in vivo.
|
28572530 |
2017 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In human clinical specimens, insulin-like growth factor I receptor was inversely correlated with miR-100 in osteosarcoma tissues.
|
26306402 |
2016 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of miR-194 inhibited tumor growth and metastasis of osteosarcoma probably by downregulating CDH2 and IGF1R. miR-194 may prove to be a promising therapeutic agent for osteosarcoma.
|
25096247 |
2014 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, PKC can be activated by several receptor tyrosine kinases implicated in osteosarcoma, including the ERBB family (EGFR, Her-2 and Her-4 in osteosarcoma), IGF1R, FGF, and others.
|
24924170 |
2014 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As a consequence, the expression of IGF1R and IGF2 was found in human OS with higher strong reactivity rate compared with the NTT (85.0 percent vs 50.0 percent, P=0.022; 95.0 percent vs 100.0 percent, P=0.042), elevating with the ascending order of tumor malignancy.
|
23527719 |
2013 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS.
|
23507142 |
2013 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IGF-1R protein was closely associated with surgical stage and distant metastasis of osteosarcoma patients.
|
21866554 |
2012 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the overexpression of IGF-1R gene might play important roles in chemoresistance of osteosarcoma cells, and lentivirus-mediated RNAi targeting IGF-1R would be an attractive anti-cancer strategy to chemosensitization of osteosarcoma cell.
|
20376536 |
2010 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line.
|
15055356 |
2004 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate whether the IGF-IR is a physiological target for p53 in osteosarcoma cells.
|
9492043 |
1998 |