IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Disease: Senile Plaques ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.020 Biomarker disease BEFREE IGF-2 attenuates memory decline, oxidative stress, cell apoptosis and amyloid plaques in the AD mouse model Tg2576 by activating the PI3K/AKT/CREB signaling pathway. 31266549 2019
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.020 Biomarker disease BEFREE Additionally, all beta-amyloid-containing neuritic plaques in the hippocampal and cortical regions of APP and APP+PS1 transgenic mice were immunopositive for both lysosomal enzymes, whereas only a subset of the plaques displayed IGF-II/M6P receptor immunoreactivity. 17561313 2009