Dementia
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The progressive deposition of the beta-amyloid peptide in the brain and its microvasculature is an invariant feature of Alzheimer's disease that appears to precede the onset of dementia by many years.
|
7504355 |
1993 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deposition of beta-amyloid peptide in the brain is an early event in Alzheimer's disease, the most common cause of dementia.
|
8140621 |
1994 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since the report of a double mutation at codons 670 and 671 of the amyloid precursor protein (APP) gene identified in two Swedish families with clinically diagnosed Alzheimer's disease (AD), a carrier with dementia has died.
|
8028788 |
1994 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Hereditary cerebral hemorrhage with amyloidosis, Dutch type, caused by a mutation at codon 693 of the amyloid beta precursor protein gene, is characterized by amyloid beta deposition resulting in recurrent strokes and dementia.
|
9225691 |
1997 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, one patient with a mutation in the APP gene did harbour a novel mtDNA mutation (G to C at position 5705 in the tRNAAsn gene) that might have contributed to the very early onset of dementia in this individual.
|
9425253 |
1997 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The dementia in patients with the APP692 mutation was compatible with Alzheimer's disease both clinically and neuropathologically.
|
11004129 |
2000 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
AMY plaques are consistently present in familial AD due to presenilin-1 (PS-1), PS-2, and amyloid precursor protein mutations, and they can begin to accumulate before the emergence of dementia.
|
10636133 |
2000 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We will focus on the regulation of beta-APP cleavage through diverse signal transduction mechanisms and discuss possible points of therapeutic intercession in what has been postulated to be a seminal molecular step in the cascade of events terminating in the onset of dementia, loss of neurons, and eventual death from Alzheimer's disease.
|
10702374 |
2000 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We suggest instead that APP normally functions in the brain as a cell surface signaling molecule, and that a disruption of this normal function of APP is at least one cause of the neurodegeneration and consequent dementia in AD.
|
11119687 |
2000 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We report a mutation at a novel site in APP in a three-generation Iowa family with autosomal dominant dementia beginning in the sixth or seventh decade of life.
|
11409420 |
2001 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Ischemic lesions are characteristic of several hereditary CAA syndromes, including a recently described mutation of the amyloid precursor protein associated with dementia (but not hemorrhagic stroke) in an Iowa family.
|
11901242 |
2002 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear.
|
11773429 |
2002 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common cause of dementia that arises on a neuropathological background of amyloid plaques containing beta-amyloid (A beta) derived from amyloid precursor protein (APP) and tau-rich neurofibrillary tangles.
|
12223532 |
2002 |
Dementia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Factors which influence Abeta levels, rather than overexpression of APP, may account for the differences in age at onset of dementia in Down's syndrome.
|
11983636 |
2002 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is a rare autosomal dominant disorder caused by an amyloid-beta precursor protein (AbetaPP) 693 mutation that clinically leads to recurrent hemorrhagic strokes and dementia.
|
14678776 |
2003 |
Dementia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Patients who progressed to DAT at the 2-year follow-up (n = 12) showed a significant decrease of baseline platelet APP forms ratio values (mean +/- SD, 0.36 +/- 0.28) compared with stable MCI subjects (mean +/- SD, 0.73 +/- 0.32) (P<.01) and patients who developed other types of dementia (mean +/- SD, 0.83 +/- 0.27) (P =.03).
|
14676049 |
2003 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here frame-shift ubiquitin-B and amyloid precursor protein were immunochemically shown to exist in the brain of high pathology control (HPC) patients with AD pathology but without prior dementia.
|
12893422 |
2003 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The most common familial early onset dementia mutations are found in the genes involved in Alzheimer's disease; the amyloid precursor protein (APP) and the presenilin 1 and 2 (PSEN1 and 2) genes; the prion protein gene (PRNP) may be involved.
|
15258222 |
2004 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
APP is an important locus predicting the age at onset of dementia in people with Down syndrome.
|
15184603 |
2004 |
Dementia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Since phosphorylation/dephosphorylation mechanisms are crucial in the regulation of Tau and beta-APP, a superfamily of mitogen-activated protein kinases (MAPKs) has recently emerged as key regulators of the formation of plagues, eventually leading to dementia and AD.
|
15312913 |
2004 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three members of an Italian family with autosomal dominant dementia and multiple strokes had the A713T mutation of the APP gene.
|
15365148 |
2004 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia.
|
15311281 |
2004 |
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APP is an important locus predicting the age at onset of dementia in people with Down syndrome.
|
15184603 |
2004 |
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This observation has several implications: APP processing abnormalities, believed to be a very early change in Alzheimer disease in neuronal compartment, does occur in extraneuronal tissues, such as platelets, thus suggesting that Alzheimer disease is a systemic disorder; further, our data strongly indicate that a differential level of platelet APP forms can be considered a potential peripheral marker of Alzheimer disease allowing for discrimination between Alzheimer and other types of dementia with good sensitivity and specificity.
|
15363602 |
2004 |