|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this type of dementia remains controversial.
|
16125396 |
2005 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Transmembrane proteins BRI2 and amyloid precursor protein (APP) co-localize with amyloid beta (Abeta) lesions in sporadic Alzheimer disease and mutations in both precursor proteins are linked to early-onset familial cases of cerebral amyloidosis associated with dementia and/or cerebral hemorrhage.
|
16027166 |
2005 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The pathology of Alzheimer's disease (AD) shows a significant correlation between beta-amyloid peptide (betaAP) deposition and the clinical severity of dementia.
|
15755621 |
2005 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Even though the idea that amyloid beta peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein and tau alterations in this type of dementia remains controversial.
|
16677790 |
2006 |
|
Dementia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Down's syndrome patients develop dementia similar to Alzheimer's disease and show elevated levels of amyloid precursor protein in brain.
|
16815323 |
2006 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.
|
16651889 |
2006 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Variation in the presenilin gene shifts the cleavage site of amyloid precursor protein producing an insoluble peptide Abeta(42) (instead of Abeta(40), which is soluble when produced in restricted amount), which is prone to aggregation in the brain in the form of amyloid plaques not only in Alzheimer's disease (AD) but also in other degenerative dementias.
|
17627113 |
2007 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
During the last 20 years, an expanding body of research has elucidated the central role of amyloid precursor protein (APP) processing and amyloid beta peptide (Abeta) production in the risk, onset, and progression of the neurodegenerative disorder Alzheimer's disease (AD), the most common form of dementia.
|
17716740 |
2007 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.
|
17339876 |
2007 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
LHGDN |
APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage.
|
17442758 |
2007 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in genes directly associated with the amyloid cascade (APP, PS1, PS2) are only present in less than 5% of the AD population; however, the presence of the APOE-4 allele in the apolipoprotein E (APOE) gene represents a major risk factor for more than 40% of patients with dementia.
|
18344047 |
2008 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
|
18300294 |
2008 |
|
Dementia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.
|
18541797 |
2008 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The E693Delta mutation within the amyloid precursor protein (APP) has been suggested to cause dementia via the enhanced formation of synaptotoxic amyloid beta (Abeta) oligomers.
|
19164507 |
2009 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
LHGDN |
Association between progranulin and beta-amyloid in dementia with Lewy bodies.
|
18955727 |
2009 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Amyloid precursor protein (APP) has been implicated in the pathogenesis of Alzheimer disease, and the accumulation of APP products ultimately leads to the familiar histopathological and clinical manifestations associated with this most common form of dementia.
|
20225047 |
2010 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Effect of early intervention with extract of Huannao Yicong Decoction (还脑益聪方) on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia.
|
21660677 |
2011 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The Arctic APP mutation (E693G) leads to dementia with clinical features similar to Alzheimer disease (AD), but little is known about the pathogenic mechanism of this mutation.
|
19329229 |
2011 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Overexpression of DSCAM in Down syndrome (DS) may be involved in the pathogenesis of mental retardation through an inhibitory action on synaptogenesis/neurite outgrowth, and in the precocious dementia associated with an amyloid precursor protein (APP) dosage effect with enhanced plaque formation.
|
21241773 |
2011 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe a novel missense mutation in the amyloid precursor protein (APP) causing a lysine-to-asparagine substitution at position 687 (APP770; herein, referred to as K16N according to amyloid-β (Aβ) numbering) resulting in an early onset dementia with an autosomal dominant inheritance pattern.
|
22514144 |
2012 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
In order to assess the frequency of mutations in the known Alzheimer's disease causative genes in Turkish dementia patients we screened amyloid precursor protein (APP), PSEN1 and PSEN2 for mutations in a cohort of 98 Turkish dementia families.
|
22503161 |
2012 |
|
Dementia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genetic studies show that a simple duplication of the Aβ precursor (APP) gene, as occurs in Down syndrome (trisomy 21), with a 1.5-fold increase in expression, can cause dementia with the complete AD associated neuropathology.
|
22300406 |
2012 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series.
|
21193246 |
2012 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline.
|
22727994 |
2012 |
|
Dementia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The Arctic APP mutation (E693G) within the amyloid β (Aβ) domain of amyloid precursor protein (APP) leads to dementia with clinical features similar to Alzheimer's disease (AD), which is believed to be mediated via increased formation of protofibrils.
|
21880397 |
2012 |