APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Cognitive deterioration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0854193
Disease: Cognitive deterioration
Cognitive deterioration 		0.030 Biomarker disease BEFREE Reduced TMAO by 3,3-Dimethyl-1-butanol (DMB) treatment ameliorated the cognitive deterioration and long-term potentiation (LTP) in APP/PS1 mice. 31612864 2019
CUI: C0854193
Disease: Cognitive deterioration
Cognitive deterioration 		0.030 Biomarker disease BEFREE On the pathway level, chemokine signaling and T cell receptor signaling pathway played the key role in cognition impairments of two models, while cytokine-cytokine receptor interaction and natural killer cell mediated cytotoxicity were more important in cognitive deterioration of SAMP8 mice than APP/PS1 mice. 27049828 2016
CUI: C0854193
Disease: Cognitive deterioration
Cognitive deterioration 		0.030 GeneticVariation disease BEFREE White matter lesions and cognitive deterioration in presymptomatic carriers of the amyloid precursor protein gene codon 693 mutation. 8599557 1996