Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the association between renal cell carcinoma (RCC) risk and single nucleotide polymorphisms (SNPs) on IL-4/IL-13/IL-4R was assessed.
|
30472377 |
2019 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study is purpose to analyzing the interleukin-4(IL-4) polymorphisms associated with RCC risk from Han Chinese population.
|
29137245 |
2017 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When stratified by cancer type, we observed that the IL-4 rs2243250 polymorphism was significantly associated with decreased oral cancer risk and increased renal cell cancer risk (for oral cancer, TT vs. CC: odds ratio (OR) = 0.40, 95 % confidence interval (95 % CI) 0.19-0.84, P heterogeneity = 0.662, P = 0.016; TT/CT vs. CC: OR = 0.45, 95 % CI 0.22-0.94, P heterogeneity = 0.407, P = 0.033; and for renal cell cancer, TT vs. CC: OR = 1.98, 95 % CI 1.06-3.69, P heterogeneity = 0.535, P = 0.031; TT vs.
|
23572437 |
2013 |
Renal Cell Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We reported previously that IL-4 induced cell cycle arrest in G1 phase through an increase in p21(WAF1/CIP1) expression in human renal cell carcinoma (RCC) cell lines.
|
23935100 |
2013 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between six functional polymorphisms of IL-4, IL-13, and IL-4R genes and susceptibility to renal cell cancer in a hospital-based study, including 620 renal cell carcinoma (RCC) patients and 623 controls.
|
22317767 |
2012 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the IL-4-590 T>C polymorphism is involved in susceptibility to developing RCC in Chinese populations.
|
20618516 |
2010 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association was found between the IL4 R alpha Val/Val genotype and increased risk of RCC (OR: 3.45, CI: 1.15-10.38, P: 0.04).
|
19548368 |
2009 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL4 haplotype -589T-33T and -589C-33C were found with a frequency of 0.069 and 0.925, respectively, which represents a two-fold decrease of IL4 haplotype -589T-33T (P < .01) and an increase of IL4 haplotype -589C-33C frequency (P < .05) in metastatic RCC compared with other white reference study populations.
|
17327605 |
2007 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we reported that IL-4 suppressed proliferation of human renal cell carcinoma (RCC) cell lines in vitro.
|
15365257 |
2004 |
Renal Cell Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of variant alleles that enhance signaling of IL-4 were significantly related to an increased risk of RCC.
|
12171893 |
2002 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of various immune manipulation strategies in parallel, bulk PBMCs treated with FP (0.34 microg/ml) plus IL-4 (1000 units/ml) for 1 week and restimulated weekly with FP plus IL-2 (20 IU/ml) induced maximal growth expansion of active T cells expressing the T-cell receptor and specific anti-RCC cytotoxicity, which could be blocked by the addition of anti-HLA class I, anti-CD3, or anti-CD8 antibodies.
|
11691814 |
2001 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings help define the biochemical modes of action of IFN-gamma and IL-4 and their potential in the biological therapy of renal cell carcinoma.
|
9067284 |
1997 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The stable transfection of RCC cells with the gamma c chain gene did not significantly change their sensitivity to IL4(38-37)-PE38KDEL.
|
8660841 |
1996 |
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though IL-13 and IL-4 are homologues and IL-4R and IL-13R have been proposed to share a receptor subunit, IL-4 did not compete for the cytotoxicity mediated by IL13-toxin on RCC.
|
8639793 |
1996 |
Renal Cell Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The function of IL-4R expression on RCC tumor cells was further determined by investigating the effect of IL-4 on tumor cell growth in vitro and comparing it with IL-4 effect on growth of normal fibroblast and endothelial cell lines.
|
8423237 |
1993 |