|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-4 signaling through the IL-4 receptor α (IL-4Rα) chain on CD4(+) T cells leads to TH2 cell differentiation in vitro, implying that IL-4Rα-responsive CD4(+) T cells are critical for the induction of allergic asthma.
|
26688514 |
2016 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic association of key Th1/Th2 pathway candidate genes, IRF2, IL6, IFNGR2, STAT4 and IL4RA, with atopic asthma in the Indian population.
|
25994869 |
2015 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analyses found that the IL4RA I50V polymorphism was significantly associated with asthma risk in Asians (OR = 1.72, 95% CI 1.31-2.25, P<0.0001), pediatric asthma risk (OR = 1.50, 95% CI 1.13-1.99, P = 0.005), and atopic asthma risk (OR = 1.88, 95% CI 1.27-2.79, P = 0.002).
|
23922687 |
2013 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The R551 IL4R variant was significantly associated with increased risk of asthma, most notably atopic asthma (combined OR, 1.6; P = .004).
|
17586032 |
2007 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we showed a significant association between the IL4R haplotype containing the alleles T-3223, V50 and R551 (TVR) of the IL4R gene, and susceptibility to atopic asthma, with a frequency of 6.5% in the patients compared with 1% in the controls (P<0.0005).
|
15479272 |
2004 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the IL4RA gene does not seem to play an important role in genetic predisposition to atopic asthma in the population tested.
|
14641543 |
2003 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the IL-4R alpha chain 576R/R genotypes confer genetic susceptibility to allergic asthma in Chinese.
|
12940513 |
2003 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed a strong association between the IL4-34T/-589T haplotype and asthma per se (P=0.041), and a strong association between the IL4RA I50/Q576 haplotype and atopic asthma (P=0.006).
|
12911786 |
2003 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of polymorphisms in the interleukin-4 receptor (alpha) gene with atopic asthma in patients from western Mexico.
|
12358844 |
2002 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to replicate this association and confirm the possible role of the Ile50Val polymorphism of IL4R in the etiology of atopic asthma in a Japanese population.
|
10390422 |
1999 |