|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
In that study, a single nucleotide polymorphism (SNP) (rs3106653) in the KCNJ3 (potassium inwardly rectifying channel, subfamily J, member 3) gene located at 2q24.1 showed association with schizophrenia in two independent sample sets.
|
21927946 |
2012 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
In that study, a single nucleotide polymorphism (SNP) (rs3106653) in the KCNJ3 (potassium inwardly rectifying channel, subfamily J, member 3) gene located at 2q24.1 showed association with schizophrenia in two independent sample sets.
|
21927946 |
2012 |
|
Dental caries
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.
|
31235808 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
To investigate possible tumor-initiating properties, benign MCF10A and malign MCF7 mammary epithelial cells were engineered to overexpress GIRK1 neoplasia associated vital parameters and resting potentials were measured and compared to controls.
|
31848385 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Overexpression the KCNJ3, a gene that encodes subunit 1 of G-protein activated inwardly rectifying K(+) channel (GIRK1) in the primary tumor has been found to be associated with reduced survival times and increased lymph node metastasis in breast cancer patients.
|
27519272 |
2016 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Expression of the GLS1 splice variant KGA was found to be decreased in tumors compared with normal lung tissue.
|
22892846 |
2012 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The GAC mRNA/KGA mRNA expression ratio was as a rule higher in the neoplastic than in control tissues, irrespective of the cell type dominating in the tumor or tumor malignancy.
|
17940881 |
2008 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The overall and stage I survival rates for patients with high GIRK1 gene expressed tumors was significantly worse than for those individuals whose tumors had low GIRK1 expression (p = 0.0004 for the overall group; p = 0.0376 for stage I).
|
15541182 |
2004 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
We found that GIRK1 overexpression correlated with lymph node metastasis (P < 0.0029), and overexpression was greatest in tumors with more than one positive lymph node.
|
11212253 |
2001 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Thus, GIRK1 regulated cellular pathways in mammary epithelial cells are likely to contribute to the development and progression of breast cancer.
|
31848385 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Excessive expression of subunit 1 of GIRK1 in ER<sup>+</sup> breast tumors is associated with reduced survival times and increased lymph node metastasis in patients.
|
31848385 |
2019 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The current study provides insight into the cellular and molecular consequences of KCNJ3 overexpression in breast cancer cells and the mechanism upon clinical outcome in patients suffering from breast cancer.
|
27519272 |
2016 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry.
|
27698251 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overexpression the KCNJ3, a gene that encodes subunit 1 of G-protein activated inwardly rectifying K(+) channel (GIRK1) in the primary tumor has been found to be associated with reduced survival times and increased lymph node metastasis in breast cancer patients.
|
27519272 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Increased expression levels of KCNJ3 have been correlated with lymph node metastases and poor prognosis in patients with breast cancer, suggesting a prognostic role of KCNJ3 We aimed to establish protocols for the detection of KCNJ3 in formalin-fixed, paraffin-embedded (FFPE) breast cancer tissue.
|
27698251 |
2016 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The very high abundance of mRNA's encoding GIRK1 together with the presence of GIRK1 protein suggests a pathophysiological role in breast cancer.
|
20512921 |
2010 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
GIRK1 gene expression was significantly associated with lymph node metastasis, stage (p = 0.0194 for lymph node metastasis; p = 0.0207 for stage).
|
15541182 |
2004 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Overexpression of the G-protein inwardly rectifying potassium channel 1 (GIRK1) in primary breast carcinomas correlates with axillary lymph node metastasis.
|
11212253 |
2001 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results indicate that GIRK1 may be useful as a biomarker for lymph node metastasis and possibly a pharmaceutical target.
|
11212253 |
2001 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
Thus, GIRK1 regulated cellular pathways in mammary epithelial cells are likely to contribute to the development and progression of breast cancer.
|
31848385 |
2019 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Critical evaluation of KCNJ3 gene product detection in human breast cancer: mRNA in situ hybridisation is superior to immunohistochemistry.
|
27698251 |
2016 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The current study provides insight into the cellular and molecular consequences of KCNJ3 overexpression in breast cancer cells and the mechanism upon clinical outcome in patients suffering from breast cancer.
|
27519272 |
2016 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
The very high abundance of mRNA's encoding GIRK1 together with the presence of GIRK1 protein suggests a pathophysiological role in breast cancer.
|
20512921 |
2010 |
|
Sinus Node Dysfunction (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, human cardiac GIRK channels are important for heart rate regulation and subsequently, genes encoding their subunits Kir3.1 and Kir3.4 ( KCNJ3 and KCNJ5) are potential candidates for inherited SND in human.
|
30645171 |
2019 |