Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Multiple oncogenic processes are initiated at the cell surface, where KRAS* physically and functionally interacts to direct signalling that is essential for malignant transformation and tumour maintenance.
|
30918400 |
2019 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Activating mutations of an isoform of the RAS protein, KRAS, are found in almost all PDAC cases and occur during early stages of malignant transformation.
|
31341034 |
2019 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
KRAS is a driver mutation for malignant transformation.
|
30283732 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The objective of the article is to evaluate KRAS and BRAF mutations as potential genetic markers for early detection of malignant transformation, we used an ultrasensitive technique to detect tissue expression of KRAS and BRAF mutations in endoscopic biopsies from 61 adult patients under follow-up after treatment for EA.
|
28873491 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study assessed mutations in KRAS and p53 gene in blood as a screening tool for malignant transformation in CP patients.
|
29303908 |
2018 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
|
29779136 |
2018 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Specifically, mutated KRAS is a documented driver for malignant transformation, occurring early during the pathogenesis of cancers such as lung and pancreatic adenocarcinomas.
|
28484014 |
2017 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The lower incidence of KRAS mutations in liver MCNs may also explain why the risk of malignant transformation in liver MCNs is lower than that in pancreatic MCNs.
|
28570009 |
2017 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro.
|
26951514 |
2016 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, these data suggest that SIRT1 is involved in HQ-induced malignant transformation associated with suppressing p53 signaling and activation of KRAS.
|
27515134 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, here we determined whether KRAS activation is critical in causing and maintaining Cd-induced malignant transformation in CTPE cells.
|
27510461 |
2016 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To address this hypothesis, we showed that low dose irradiation, at doses of 0.1 Gray (Gy); predominantly provide defensive response against oncogenic KRAS -induced malignant transformation in human cells through the induction of antioxidants without causing cell death and acts as a critical regulator for the attenuation of reactive oxygen species (ROS).
|
26515758 |
2015 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The molecular profile of the adenocarcinoma showed a mutation in KRAS and wild-type BRAF, which might be associated with malignant transformation of intracranial mature teratomas.
|
25039399 |
2015 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Moreover, we also submit that this KRAS mutation might contribute to identify malignant transformation of a MCT and suggest possible effect on targeted treatment decisions for anti-epidermal growth factor receptor (EGFR) therapy in metastasized patients.
|
25297496 |
2014 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We provide evidence that MUTYH-associated-polyposis carcinogenesis is characterized by the occurrence of specific mutations in both KRAS and phylogenetically conserved genes of mitochondrial DNA which are involved in controlling oxidative phosphorylation; this implies the existence of a colorectal tumorigenesis in which changes in mitochondrial functions cooperate with RAS-induced malignant transformation.
|
23599153 |
2013 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, KRAS-mediated malignant transformation occurred in a new HPDE-TGF-β resistant (TβR) cell line that completely lacks Smad4 protein expression and is resistant to the mito-inhibitory activity of TGF-β.
|
24386371 |
2013 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, recent work in pancreatic cancer mouse models proposes that inactivation of the CDKN2A tumour suppressor locus is the molecular switch required for senescence evasion and unleashed K-Ras driven malignant transformation in the pancreas.
|
23408353 |
2013 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Retroviral expression of K-Ras(V12) induced autophagic vacuole formation and malignant transformation in human breast epithelial cells.
|
21300795 |
2011 |
Malignant transformation
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although a combination of four genetic alterations, including hTERT overexpression, inactivation of the pRB and p53 pathways, and KRAS activation, is insufficient for normal human small airway epithelial cells to be fully transformed, expression of one additional oncogene induces malignant transformation.
|
21447735 |
2011 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
However, the functional role of KRAS mutations in the malignant transformation of normal pancreatic duct epithelial cells into cancer cells remains unknown.
|
18374152 |
2008 |
Malignant transformation
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.
|
18549880 |
2008 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results show that BRAF, KRAS and PIK3CA mutations occur prior to malignant transformation demonstrating that these oncogenic alterations are primary genetic events in colorectal carcinogenesis.
|
18782444 |
2008 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
At present, K-ras-2 mutation is not useful for differentiating pancreatic cancer from chronic pancreatitis or the identification of patients with chronic pancreatitis at risk for malignant transformation.
|
11677475 |
2001 |
Malignant transformation
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In adenomas mutations, particularly G-T transversions, in the K-ras gene could indicate a propensity to malignant transformation.
|
8682594 |
1996 |