LEP, leptin, 3952

N. diseases: 114; N. variants: 3
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 GeneticVariation disease UNIPROT Biologically inactive leptin and early-onset extreme obesity. 25551525 2015
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 GeneticVariation disease UNIPROT A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 Biomarker disease CTD_human
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia. 18515891 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. 9502777 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Stevia-derived compounds attenuate the toxic effects of ectopic lipid accumulation in the liver of obese mice: a transcriptomic and metabolomic study. 25554529 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human The effect of endurance exercise on both skeletal muscle and systemic oxidative stress in previously sedentary obese men. 24042701 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Biologically inactive leptin and early-onset extreme obesity. 25551525 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Leptin-deficient obese (ob/ob) mice and wild-type counterparts (C57/BL6 mice) were exposed to UVB radiation (120 mJ/cm(2)) on alternate days for 1 month. 20122948 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight. 17517446 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Sequencing of the leptin gene may need to be considered in hyperphagic, severely obese children with detectable levels of circulating leptin. 26186301 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. 25086370 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice. 19913045 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress. 28698385 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Congenital leptin deficiency is associated with severe early-onset obesity in humans. 9202122 1997
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker disease CTD_human In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice. 27712037 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker disease CTD_human Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. 24525044 2014
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker disease CTD_human Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. 23839791 2014
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.600 Biomarker disease CTD_human A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. 19716478 2009