LEP, leptin, 3952

N. diseases: 114; N. variants: 3
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 Biomarker disease CTD_human
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic disease CTD_human Congenital leptin deficiency is associated with severe early-onset obesity in humans. 9202122 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Congenital leptin deficiency is associated with severe early-onset obesity in humans. 9202122 1997
CUI: C3554224
Disease: LEPTIN DEFICIENCY OR DYSFUNCTION
LEPTIN DEFICIENCY OR DYSFUNCTION 		0.800 GeneticVariation disease UNIPROT A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.700 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. 9502777 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Therapeutic disease CTD_human Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. 9502777 1998
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0020619
Disease: Hypogonadism
Hypogonadism 		0.650 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0028756
Disease: Obesity, Morbid
Obesity, Morbid 		0.400 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0028756
Disease: Obesity, Morbid
Obesity, Morbid 		0.400 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0948896
Disease: Primary hypogonadism
Primary hypogonadism 		0.400 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0948896
Disease: Primary hypogonadism
Primary hypogonadism 		0.400 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.400 Biomarker disease PSYGENET These potential pathways are illustrated with the specific example of the association of the human leptin (OB) gene with obesity and major depressive disorders in humans. 9754619 1998
CUI: C0271623
Disease: Hypogonadotropic hypogonadism
Hypogonadotropic hypogonadism 		0.350 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0271623
Disease: Hypogonadotropic hypogonadism
Hypogonadotropic hypogonadism 		0.350 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C1257963
Disease: Endogenous Hyperinsulinism
Endogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C1257964
Disease: Exogenous Hyperinsulinism
Exogenous Hyperinsulinism 		0.300 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.300 Biomarker disease CTD_human Insulin depletion leads to adipose-specific cell death in obese but not lean mice. 9826672 1998
CUI: C3489396
Disease: Hypogonadism, Isolated Hypogonadotropic
Hypogonadism, Isolated Hypogonadotropic 		0.300 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C3489396
Disease: Hypogonadism, Isolated Hypogonadotropic
Hypogonadism, Isolated Hypogonadotropic 		0.300 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.300 Therapeutic disease CTD_human Leptin in gastroprotection induced by cholecystokinin or by a meal. Role of vagal and sensory nerves and nitric oxide. 10422768 1999