LEP, leptin, 3952

N. diseases: 114; N. variants: 3
Disease: Depressive disorder ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys? 25629253 2015
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Our results suggest an involvement of leptin in antidepressant action and cognitive function in depression with genetic polymorphisms in the leptin gene, decreased leptin gene expression and leptin deficiency in serum being risk factors for resistance to antidepressant therapy in depressed patients. 23026132 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. 22932068 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. 22408745 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse. 23251447 2012