LMAN1, lectin, mannose binding 1, 3998

N. diseases: 30; N. variants: 6
Disease: Microsatellite instability-high colorectal cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4544822
Disease: Microsatellite instability-high colorectal cancer
Microsatellite instability-high colorectal cancer 		0.010 GeneticVariation disease BEFREE Among 28 candidate genes, LMAN1/ERGIC53, a mannose-specific lectin mediating endoplasmatic reticulum (ER)-to-Golgi transit of glycosylated proteins, showed high mutation frequency in MSI-H colorectal cancer cell lines (52%; 12 of 23), carcinomas (45%; 72 of 161), and adenomas (40%; 8 of 20). 19118014 2009