MIR133A1, microRNA 133a-1, 406922

N. diseases: 8; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.300 Therapeutic phenotype CTD_human MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. 19893015 2010
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.300 Therapeutic disease CTD_human MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. 19893015 2010
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.200 Biomarker phenotype RGD A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells. 26512955 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 AlteredExpression disease BEFREE Consistently, the level of miR‑133a‑1 in HCC was reduced markedly compared to normal tissues (P<0.001) based on TCGA data, and the AUC value of low miR‑133a‑1 expression for HCC diagnosis was 0.670 (P<0.001). 29138825 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.010 GeneticVariation disease BEFREE However, the C alleles of both mir-133a-1 rs8089787 (C vs. T, OR = 1.867, 95% CI: 1.486-2.345) and rs9948906 (C vs. T, OR = 2.177, 95% CI: 1.690-2.804) were significantly associated with an increased risk for asthma. 27383317 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2. 26107945 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2. 26107945 2015
CUI: C0023976
Disease: Long QT Syndrome
Long QT Syndrome 		0.010 Biomarker disease BEFREE Our findings indicate that sequence variants of miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2 are not a cause of LQTS in this cohort. 24809446 2014